Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

Lam C. Tsoi, Sarah L. Spain, Eva Ellinghaus, Philip E. Stuart, Francesca Capon, Jo Knight, Trilokraj Tejasvi, Hyun M. Kang, Michael H. Allen, Sylviane Lambert, Stefan W. Stoll, Stephan Weidinger, Johann E. Gudjonsson, Sulev Koks, Külli Kingo, Tonu Esko, Sayantan Das, Andres Metspalu, Michael Weichenthal, Charlotta Enerback, Gerald G. Krueger, John J. Voorhees, Vinod Chandran, Cheryl F. Rosen, Proton Rahman, Dafna D. Gladman, Andre Reis, Rajan P. Nair, Andre Franke, Jonathan N.W.N. Barker, Goncalo R. Abecasis (), Richard C. Trembath () and James T. Elder ()
Additional contact information
Lam C. Tsoi: Center for Statistical Genetics, University of Michigan
Sarah L. Spain: King’s College London
Eva Ellinghaus: Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
Philip E. Stuart: University of Michigan
Francesca Capon: King’s College London
Jo Knight: Neuroscience Research, Centre for Addiction and Mental Health
Trilokraj Tejasvi: University of Michigan
Hyun M. Kang: Center for Statistical Genetics, University of Michigan
Michael H. Allen: King’s College London
Sylviane Lambert: University of Michigan
Stefan W. Stoll: University of Michigan
Stephan Weidinger: University Hospital, Schleswig-Holstein, Christian-Albrechts-University
Johann E. Gudjonsson: University of Michigan
Sulev Koks: Centre of Translational Medicine and Centre for Translational Genomics, University of Tartu
Külli Kingo: University of Tartu
Tonu Esko: Estonian Genome Center, University of Tartu
Sayantan Das: Center for Statistical Genetics, University of Michigan
Andres Metspalu: Estonian Genome Center, University of Tartu
Michael Weichenthal: University Hospital, Schleswig-Holstein, Christian-Albrechts-University
Charlotta Enerback: Linköping University
Gerald G. Krueger: University of Utah
John J. Voorhees: University of Michigan
Vinod Chandran: University of Toronto, Toronto Western Hospital
Cheryl F. Rosen: University of Toronto, Toronto Western Hospital
Proton Rahman: Memorial University
Dafna D. Gladman: University of Toronto, Toronto Western Hospital
Andre Reis: Institute of Human Genetics, University of Erlangen-Nuremberg
Rajan P. Nair: University of Michigan
Andre Franke: Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
Jonathan N.W.N. Barker: King’s College London
Goncalo R. Abecasis: Center for Statistical Genetics, University of Michigan
Richard C. Trembath: Barts and the London School of Medicine and Dentistry, Queen Mary University of London
James T. Elder: University of Michigan

Nature Communications, 2015, vol. 6, issue 1, 1-8

Abstract: Abstract Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous genome-wide association studies (GWAS) and a recent meta-analysis using Immunochip data have uncovered 36 susceptibility loci. Here, we extend our previous meta-analysis of European ancestry by refined genotype calling and imputation and by the addition of 5,033 cases and 5,707 controls. The combined analysis, consisting of over 15,000 cases and 27,000 controls, identifies five new psoriasis susceptibility loci at genome-wide significance (P

Date: 2015
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DOI: 10.1038/ncomms8001

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