Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese

Changgui Li (), Zhiqiang Li, Shiguo Liu, Can Wang, Lin Han, Lingling Cui, Jingguo Zhou, Hejian Zou, Zhen Liu, Jianhua Chen, Xiaoyu Cheng, Zhaowei Zhou, Chengcheng Ding, Meng Wang, Tong Chen, Ying Cui, Hongmei He, Keke Zhang, Congcong Yin, Yunlong Wang, Shichao Xing, Baojie Li, Jue Ji, Zhaotong Jia, Lidan Ma, Jiapeng Niu, Ying Xin, Tian Liu, Nan Chu, Qing Yu, Wei Ren, Xuefeng Wang, Aiqing Zhang, Yuping Sun, Haili Wang, Jie Lu, Yuanyuan Li, Yufeng Qing, Gang Chen, Yangang Wang, Li Zhou, Haitao Niu, Jun Liang, Qian Dong, Xinde Li, Qing-Sheng Mi and Yongyong Shi ()
Additional contact information
Changgui Li: Shandong Gout Clinical Medical Center
Zhiqiang Li: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
Shiguo Liu: Shandong Gout Clinical Medical Center
Can Wang: Shandong Gout Clinical Medical Center
Lin Han: Shandong Gout Clinical Medical Center
Lingling Cui: Shandong Gout Clinical Medical Center
Jingguo Zhou: North Sichuan Medical College
Hejian Zou: The Affiliated Huashan Hospital of Fudan University
Zhen Liu: Shandong Gout Clinical Medical Center
Jianhua Chen: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
Xiaoyu Cheng: Shandong Gout Clinical Medical Center
Zhaowei Zhou: Shandong Gout Clinical Medical Center
Chengcheng Ding: Shandong Gout Clinical Medical Center
Meng Wang: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
Tong Chen: Shandong Gout Clinical Medical Center
Ying Cui: Shandong Gout Clinical Medical Center
Hongmei He: Shandong Gout Clinical Medical Center
Keke Zhang: Shandong Gout Clinical Medical Center
Congcong Yin: Shandong Gout Clinical Medical Center
Yunlong Wang: Shandong Gout Clinical Medical Center
Shichao Xing: Shandong Gout Clinical Medical Center
Baojie Li: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
Jue Ji: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
Zhaotong Jia: Shandong Gout Clinical Medical Center
Lidan Ma: Shandong Gout Clinical Medical Center
Jiapeng Niu: Shandong Gout Clinical Medical Center
Ying Xin: Shandong Gout Clinical Medical Center
Tian Liu: Shandong Gout Clinical Medical Center
Nan Chu: Shandong Gout Clinical Medical Center
Qing Yu: Shandong Gout Clinical Medical Center
Wei Ren: Shandong Gout Clinical Medical Center
Xuefeng Wang: Shandong Gout Clinical Medical Center
Aiqing Zhang: Shandong Gout Clinical Medical Center
Yuping Sun: Shandong Gout Clinical Medical Center
Haili Wang: Shandong Gout Clinical Medical Center
Jie Lu: Shandong Gout Clinical Medical Center
Yuanyuan Li: Shandong Gout Clinical Medical Center
Yufeng Qing: North Sichuan Medical College
Gang Chen: Fujian Provincial Hospital, Fujian Medical University
Yangang Wang: Shandong Gout Clinical Medical Center
Li Zhou: Henry Ford Immunology Program, Henry Ford Health System
Haitao Niu: The Affiliated Hospital of Medical College Qingdao University
Jun Liang: The Affiliated Hospital of Qingdao University Medical College
Qian Dong: The Affiliated Hospital of Qingdao University Medical College
Xinde Li: Shandong Gout Clinical Medical Center
Qing-Sheng Mi: Henry Ford Immunology Program, Henry Ford Health System
Yongyong Shi: Shandong Gout Clinical Medical Center

Nature Communications, 2015, vol. 6, issue 1, 1-6

Abstract: Abstract Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia alone is not sufficient for the development of gout arthritis. Here we conduct a multistage GWAS in Han Chinese using 4,275 male gout patients and 6,272 normal male controls (1,255 cases and 1,848 controls were genome-wide genotyped), with an additional 1,644 hyperuricemic controls. We discover three new risk loci, 17q23.2 (rs11653176, P=1.36 × 10−13, BCAS3), 9p24.2 (rs12236871, P=1.48 × 10−10, RFX3) and 11p15.5 (rs179785, P=1.28 × 10−8, KCNQ1), which contain inflammatory candidate genes. Our results suggest that these loci are most likely related to the progression from hyperuricemia to inflammatory gout, which will provide new insights into the pathogenesis of gout arthritis.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms8041 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8041

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms8041

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().