JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis

Yohei Abe, Royhan Rozqie, Yoshihiro Matsumura, Takeshi Kawamura, Ryo Nakaki, Yuya Tsurutani, Kyoko Tanimura-Inagaki, Akira Shiono, Kenta Magoori, Kanako Nakamura, Shotaro Ogi, Shingo Kajimura, Hiroshi Kimura, Toshiya Tanaka, Kiyoko Fukami, Timothy F. Osborne, Tatsuhiko Kodama, Hiroyuki Aburatani, Takeshi Inagaki () and Juro Sakai ()
Additional contact information
Yohei Abe: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Royhan Rozqie: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Yoshihiro Matsumura: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Takeshi Kawamura: Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Ryo Nakaki: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Yuya Tsurutani: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Kyoko Tanimura-Inagaki: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Akira Shiono: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Kenta Magoori: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Kanako Nakamura: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Shotaro Ogi: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Shingo Kajimura: UCSF Diabetes Center, University of California, San Francisco
Hiroshi Kimura: Graduate School of Frontier Biosciences, Osaka University
Toshiya Tanaka: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Kiyoko Fukami: Laboratory of Genome and Biosignals, Tokyo University of Pharmacy and Life Science
Timothy F. Osborne: Metabolic Disease Program, Sanford-Burnham Medical Research Institute
Tatsuhiko Kodama: Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Hiroyuki Aburatani: The Translational Systems Biology and Medicine Initiative, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo
Takeshi Inagaki: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Juro Sakai: Research Center for Advanced Science and Technology (RCAST), The University of Tokyo

Nature Communications, 2015, vol. 6, issue 1, 1-14

Abstract: Abstract Histone 3 lysine 9 (H3K9) demethylase JMJD1A regulates β-adrenergic-induced systemic metabolism and body weight control. Here we show that JMJD1A is phosphorylated at S265 by protein kinase A (PKA), and this is pivotal to activate the β1-adrenergic receptor gene (Adrb1) and downstream targets including Ucp1 in brown adipocytes (BATs). Phosphorylation of JMJD1A by PKA increases its interaction with the SWI/SNF nucleosome remodelling complex and DNA-bound PPARγ. This complex confers β-adrenergic-induced rapid JMJD1A recruitment to target sites and facilitates long-range chromatin interactions and target gene activation. This rapid gene induction is dependent on S265 phosphorylation but not on demethylation activity. Our results show that JMJD1A has two important roles in regulating hormone-stimulated chromatin dynamics that modulate thermogenesis in BATs. In one role, JMJD1A is recruited to target sites and functions as a cAMP-responsive scaffold that facilitates long-range chromatin interactions, and in the second role, JMJD1A demethylates H3K9 di-methylation.

Date: 2015
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DOI: 10.1038/ncomms8052

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