Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

Rosemary C. Bagot, Eric M. Parise, Catherine J. Peña, Hong-Xing Zhang, Ian Maze, Dipesh Chaudhury, Brianna Persaud, Roger Cachope, Carlos A. Bolaños-Guzmán, Joseph F. Cheer, Karl Deisseroth, Ming-Hu Han and Eric J. Nestler ()
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Rosemary C. Bagot: Icahn School of Medicine at Mount Sinai
Eric M. Parise: Florida State University
Catherine J. Peña: Icahn School of Medicine at Mount Sinai
Hong-Xing Zhang: Icahn School of Medicine at Mount Sinai
Ian Maze: Icahn School of Medicine at Mount Sinai
Dipesh Chaudhury: Icahn School of Medicine at Mount Sinai
Brianna Persaud: Icahn School of Medicine at Mount Sinai
Roger Cachope: University of Maryland School of Medicine
Carlos A. Bolaños-Guzmán: Florida State University
Joseph F. Cheer: University of Maryland School of Medicine
Karl Deisseroth: Stanford University
Ming-Hu Han: Icahn School of Medicine at Mount Sinai
Eric J. Nestler: Icahn School of Medicine at Mount Sinai

Nature Communications, 2015, vol. 6, issue 1, 1-9

Abstract: Abstract Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for reward and motivation, has been implicated in the pathophysiology of depression; however, the afferent source of this increased glutamate tone is not known. The NAc receives glutamatergic inputs from the medial prefrontal cortex (mPFC), ventral hippocampus (vHIP) and basolateral amygdala (AMY). Here, we demonstrate that glutamatergic vHIP afferents to NAc regulate susceptibility to chronic social defeat stress (CSDS). We observe reduced activity in vHIP in mice resilient to CSDS. Furthermore, attenuation of vHIP-NAc transmission by optogenetic induction of long-term depression is pro-resilient, whereas acute enhancement of this input is pro-susceptible. This effect is specific to vHIP afferents to the NAc, as optogenetic stimulation of either mPFC or AMY afferents to the NAc is pro-resilient. These data indicate that vHIP afferents to NAc uniquely regulate susceptibility to CSDS, highlighting an important, novel circuit-specific mechanism in depression.

Date: 2015
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DOI: 10.1038/ncomms8062

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