Muscle stem cells contribute to myofibres in sedentary adult mice

Alexandra C. Keefe, Jennifer A. Lawson, Steven D. Flygare, Zachary D. Fox, Mary P. Colasanto, Sam J. Mathew, Mark Yandell and Gabrielle Kardon ()
Additional contact information
Alexandra C. Keefe: University of Utah
Jennifer A. Lawson: University of Utah
Steven D. Flygare: University of Utah
Zachary D. Fox: University of Utah
Mary P. Colasanto: University of Utah
Sam J. Mathew: University of Utah
Mark Yandell: University of Utah
Gabrielle Kardon: University of Utah

Nature Communications, 2015, vol. 6, issue 1, 1-11

Abstract: Abstract Skeletal muscle is essential for mobility, stability and whole body metabolism, and muscle loss, for instance, during sarcopenia, has profound consequences. Satellite cells (muscle stem cells) have been hypothesized, but not yet demonstrated, to contribute to muscle homeostasis and a decline in their contribution to myofibre homeostasis to play a part in sarcopenia. To test their role in muscle maintenance, we genetically labelled and ablated satellite cells in adult sedentary mice. We demonstrate via genetic lineage experiments that, even in the absence of injury, satellite cells contribute to myofibres in all adult muscles, although the extent and timing differs. However, genetic ablation experiments showed that satellite cells are not globally required to maintain myofibre cross-sectional area of uninjured adult muscle.

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms8087 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8087

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms8087

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().