Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8+ T cells

Valérie Martinet, Sandrine Tonon, David Torres, Abdulkader Azouz, Muriel Nguyen, Arnaud Kohler, Véronique Flamand, Chai-An Mao, William H. Klein, Oberdan Leo and Stanislas Goriely ()
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Valérie Martinet: WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles
Sandrine Tonon: WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles
David Torres: WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles
Abdulkader Azouz: WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles
Muriel Nguyen: WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles
Arnaud Kohler: WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles
Véronique Flamand: WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles
Chai-An Mao: University of Texas, MD Anderson Cancer Center
William H. Klein: University of Texas, MD Anderson Cancer Center
Oberdan Leo: WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles
Stanislas Goriely: WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles

Nature Communications, 2015, vol. 6, issue 1, 1-13

Abstract: Abstract CD8+ T-cell memory phenotype and function are acquired after antigen-driven activation. Memory-like cells may also arise in absence of antigenic exposure in the thymus or in the periphery. Eomesodermin (Eomes) is a key transcription factor for the development of these unconventional memory cells. Herein, we show that type I interferon signalling in CD8+ T cells directly activates Eomes gene expression. Consistent with this observation, the phenotype, function and age-dependent expansion of ‘virtual memory’ CD8+ T cells are strongly affected in absence of type I interferon signalling. In addition, type I interferons induce a sustained expansion of ‘virtual memory’ CD8+ T cells in an Eomes-dependent fashion. We further show that the development of ‘innate thymic’ CD8+ T cells is dependent on the same pathway. In conclusion, we demonstrate that type I interferon signalling in CD8+ T cells drives Eomes expression and thereby regulates the function and homeostasis of memory-like CD8+ T cells.

Date: 2015
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DOI: 10.1038/ncomms8089

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