A common assembly module in injectisome and flagellar type III secretion sorting platforms

Ryan Q. Notti, Shibani Bhattacharya, Mirjana Lilic and C. Erec Stebbins ()
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Ryan Q. Notti: Laboratory of Structural Microbiology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Shibani Bhattacharya: New York Structural Biology Center, 89 Convent Avenue, New York, New York 10027, USA
Mirjana Lilic: Laboratory of Structural Microbiology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
C. Erec Stebbins: Laboratory of Structural Microbiology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

Nature Communications, 2015, vol. 6, issue 1, 1-11

Abstract: Abstract Translocating proteins across the double membrane of Gram-negative bacteria, type III secretion systems (T3SS) occur in two evolutionarily related forms: injectisomes, delivering virulence factors into host cells, and the flagellar system, secreting the polymeric filament used for motility. While both systems share related elements of a cytoplasmic sorting platform that facilitates the hierarchical secretion of protein substrates, its assembly and regulation remain unclear. Here we describe a module mediating the assembly of the sorting platform in both secretion systems, and elucidate the structural basis for segregation of homologous components among these divergent T3SS subtypes sharing a common cytoplasmic milieu. These results provide a foundation for the subtype-specific assembly of T3SS sorting platforms and will support further mechanistic analysis and anti-virulence drug design.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8125

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DOI: 10.1038/ncomms8125

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