Genome-wide association study of colorectal cancer identifies six new susceptibility loci

Fredrick R. Schumacher, Stephanie L. Schmit, Shuo Jiao, Christopher K. Edlund, Hansong Wang, Ben Zhang, Li Hsu, Shu-Chen Huang, Christopher P. Fischer, John F. Harju, Gregory E. Idos, Flavio Lejbkowicz, Frank J. Manion, Kevin McDonnell, Caroline E. McNeil, Marilena Melas, Hedy S. Rennert, Wei Shi, Duncan C. Thomas, David J. Van Den Berg, Carolyn M. Hutter, Aaron K. Aragaki, Katja Butterbach, Bette J. Caan, Christopher S. Carlson, Stephen J. Chanock, Keith R. Curtis, Charles S. Fuchs, Manish Gala, Edward L. Giovannucci, Stephanie M. Gogarten, Richard B. Hayes, Brian Henderson, David J. Hunter, Rebecca D. Jackson, Laurence N. Kolonel, Charles Kooperberg, Sébastien Küry, Andrea LaCroix, Cathy C. Laurie, Cecelia A. Laurie, Mathieu Lemire, David Levine, Jing Ma, Karen W. Makar, Conghui Qu, Darin Taverna, Cornelia M. Ulrich, Kana Wu, Suminori Kono, Dee W. West, Sonja I. Berndt, Stéphane Bezieau, Hermann Brenner, Peter T. Campbell, Andrew T. Chan, Jenny Chang-Claude, Gerhard A. Coetzee, David V. Conti, David Duggan, Jane C. Figueiredo, Barbara K. Fortini, Steven J. Gallinger, W. James Gauderman, Graham Giles, Roger Green, Robert Haile, Tabitha A. Harrison, Michael Hoffmeister, John L. Hopper, Thomas J. Hudson, Eric Jacobs, Motoki Iwasaki, Sun Ha Jee, Mark Jenkins, Wei-Hua Jia, Amit Joshi, Li Li, Noralene M. Lindor, Keitaro Matsuo, Victor Moreno, Bhramar Mukherjee, Polly A. Newcomb, John D. Potter, Leon Raskin, Gad Rennert, Stephanie Rosse, Gianluca Severi, Robert E. Schoen, Daniela Seminara, Xiao-Ou Shu, Martha L. Slattery, Shoichiro Tsugane, Emily White, Yong-Bing Xiang, Brent W. Zanke, Wei Zheng, Loic Le Marchand, Graham Casey, Stephen B. Gruber () and Ulrike Peters
Additional contact information
Fredrick R. Schumacher: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Stephanie L. Schmit: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Shuo Jiao: Fred Hutchinson Cancer Research Center
Christopher K. Edlund: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Hansong Wang: Epidemiology Program, University of Hawaii Cancer Center
Ben Zhang: Third Military Medical University Southwest Hospital
Li Hsu: Fred Hutchinson Cancer Research Center
Shu-Chen Huang: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Christopher P. Fischer: University of Michigan Comprehensive Cancer Center
John F. Harju: University of Michigan Comprehensive Cancer Center
Gregory E. Idos: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Flavio Lejbkowicz: Carmel Medical Center
Frank J. Manion: University of Michigan Comprehensive Cancer Center
Kevin McDonnell: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Caroline E. McNeil: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Marilena Melas: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Hedy S. Rennert: Carmel Medical Center
Wei Shi: Children’s Hospital Los Angeles
Duncan C. Thomas: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
David J. Van Den Berg: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Carolyn M. Hutter: National Cancer Institute, National Institutes of Health
Aaron K. Aragaki: Fred Hutchinson Cancer Research Center
Katja Butterbach: German Cancer Research Center (DKFZ)
Bette J. Caan: Kaiser Permanente Medical Care Program of Northern California
Christopher S. Carlson: Fred Hutchinson Cancer Research Center
Stephen J. Chanock: National Cancer Institute
Keith R. Curtis: Fred Hutchinson Cancer Research Center
Charles S. Fuchs: Brigham and Women’s Hospital
Manish Gala: Massachusetts General Hospital
Edward L. Giovannucci: Harvard Medical School
Stephanie M. Gogarten: University of Washington
Richard B. Hayes: New York University School of Medicine
Brian Henderson: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
David J. Hunter: Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health
Rebecca D. Jackson: Ohio State University
Laurence N. Kolonel: Office of Public Health Studies, University of Hawaii Manoa
Charles Kooperberg: Fred Hutchinson Cancer Research Center
Sébastien Küry: Service de Génétique Médicale, CHU Nantes
Andrea LaCroix: Fred Hutchinson Cancer Research Center
Cathy C. Laurie: University of Washington
Cecelia A. Laurie: University of Washington
Mathieu Lemire: Ontario Institute for Cancer Research
David Levine: University of Washington
Jing Ma: Harvard School of Public Health
Karen W. Makar: Fred Hutchinson Cancer Research Center
Conghui Qu: Fred Hutchinson Cancer Research Center
Darin Taverna: Phoenix College
Cornelia M. Ulrich: Fred Hutchinson Cancer Research Center
Kana Wu: Harvard School of Public Health
Suminori Kono: Kyushu University
Dee W. West: Cancer Registry of Greater California, Public Health Institute
Sonja I. Berndt: National Cancer Institute
Stéphane Bezieau: Centre Hospitalier Universitaire Hotel-Dieu
Hermann Brenner: German Cancer Research Center (DKFZ)
Peter T. Campbell: Epidemiology Research Program, American Cancer Society
Andrew T. Chan: Massachusetts General Hospital
Jenny Chang-Claude: Unit of Genetic Epidemiology, German Cancer Research Center (DKFZ)
Gerhard A. Coetzee: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
David V. Conti: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
David Duggan: Translational Genomics Research Institute
Jane C. Figueiredo: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Barbara K. Fortini: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Steven J. Gallinger: Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital
W. James Gauderman: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Graham Giles: Cancer Epidemiology Centre, Cancer Council Victoria
Roger Green: Discipline of Genetics, Memorial University of Newfoundland
Robert Haile: Stanford University
Tabitha A. Harrison: Fred Hutchinson Cancer Research Center
Michael Hoffmeister: German Cancer Research Center (DKFZ)
John L. Hopper: Centre for MEGA Epidemiology, The University of Melbourne
Thomas J. Hudson: Ontario Institute for Cancer Research
Eric Jacobs: Epidemiology Research Program, American Cancer Society
Motoki Iwasaki: Research Center for Cancer Prevention and Screening, National Cancer Center
Sun Ha Jee: Graduate School of Public Health, Yonsei University
Mark Jenkins: Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
Wei-Hua Jia: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University
Amit Joshi: Harvard School of Public Health
Li Li: Case Western Reserve University
Noralene M. Lindor: Mayo Clinic
Keitaro Matsuo: Kyushu University
Victor Moreno: Cancer Epidemiology Service, Catalan Institute of Oncology, IDIBELL
Bhramar Mukherjee: University of Michigan
Polly A. Newcomb: Cancer Prevention Program, Fred Hutchinson Cancer Research Center
John D. Potter: Cancer Prevention Program, Fred Hutchinson Cancer Research Center
Leon Raskin: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Gad Rennert: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Stephanie Rosse: Fred Hutchinson Cancer Research Center
Gianluca Severi: Cancer Epidemiology Centre, Cancer Council Victoria
Robert E. Schoen: University of Pittsburgh Medical Center
Daniela Seminara: Epidemiology and Genomics Research Program, National Cancer Institute, National Institutes of Health
Xiao-Ou Shu: Vanderbilt-Ingram Cancer Center, Vanderbilt University
Martha L. Slattery: University of Utah Health Sciences Center
Shoichiro Tsugane: Research Center for Cancer Prevention and Screening, National Cancer Center
Emily White: Fred Hutchinson Cancer Research Center
Yong-Bing Xiang: Shanghai Cancer Institute
Brent W. Zanke: The University of Ottawa
Wei Zheng: Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine
Loic Le Marchand: Epidemiology Program, University of Hawaii Cancer Center
Graham Casey: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Stephen B. Gruber: USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Ulrike Peters: Fred Hutchinson Cancer Research Center

Nature Communications, 2015, vol. 6, issue 1, 1-7

Abstract: Abstract Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P

Date: 2015
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DOI: 10.1038/ncomms8138

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