AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

Albert Herms, Marta Bosch, Babu J.N. Reddy, Nicole L. Schieber, Alba Fajardo, Celia Rupérez, Andrea Fernández-Vidal, Charles Ferguson, Carles Rentero, Francesc Tebar, Carlos Enrich, Robert G. Parton, Steven P. Gross and Albert Pol ()
Additional contact information
Albert Herms: Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Marta Bosch: Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Babu J.N. Reddy: UC Irvine
Nicole L. Schieber: The Institute for Molecular Bioscience, The University of Queensland
Alba Fajardo: Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Celia Rupérez: Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Andrea Fernández-Vidal: Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Charles Ferguson: The Institute for Molecular Bioscience, The University of Queensland
Carles Rentero: Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Francesc Tebar: Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Carlos Enrich: Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Robert G. Parton: The Institute for Molecular Bioscience, The University of Queensland
Steven P. Gross: UC Irvine
Albert Pol: Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

Nature Communications, 2015, vol. 6, issue 1, 1-14

Abstract: Abstract Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally along microtubules (MTs), the role of LD motion and whether it facilitates interaction with other organelles are unclear. Here we show that during nutrient starvation, LDs and mitochondria relocate on detyrosinated MT from the cell centre to adopt a dispersed distribution. In the cell periphery, LD–mitochondria interactions increase and LDs efficiently supply FAs for mitochondrial beta-oxidation. This cellular adaptation requires the activation of the energy sensor AMPK, which in response to starvation simultaneously increases LD motion, reorganizes the network of detyrosinated MTs and activates mitochondria. In conclusion, we describe the existence of a specialized cellular network connecting the cellular energetic status and MT dynamics to coordinate the functioning of LDs and mitochondria during nutrient scarcity.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8176

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DOI: 10.1038/ncomms8176

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