Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue

Kai Wang, Wenzhi Sun, Christopher T. Richie, Brandon K. Harvey, Eric Betzig and Na Ji ()
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Kai Wang: Janelia Research Campus, Howard Hughes Medical Institute
Wenzhi Sun: Janelia Research Campus, Howard Hughes Medical Institute
Christopher T. Richie: Intramural Research Program, National Institute on Drug Abuse
Brandon K. Harvey: Intramural Research Program, National Institute on Drug Abuse
Eric Betzig: Janelia Research Campus, Howard Hughes Medical Institute
Na Ji: Janelia Research Campus, Howard Hughes Medical Institute

Nature Communications, 2015, vol. 6, issue 1, 1-6

Abstract: Abstract Adaptive optics by direct imaging of the wavefront distortions of a laser-induced guide star has long been used in astronomy, and more recently in microscopy to compensate for aberrations in transparent specimens. Here we extend this approach to tissues that strongly scatter visible light by exploiting the reduced scattering of near-infrared guide stars. The method enables in vivo two-photon morphological and functional imaging down to 700 μm inside the mouse brain.

Date: 2015
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DOI: 10.1038/ncomms8276

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