Physical principles of membrane remodelling during cell mechanoadaptation

Anita Joanna Kosmalska, Laura Casares, Alberto Elosegui-Artola, Joseph Jose Thottacherry, Roberto Moreno-Vicente, Víctor González-Tarragó, Miguel Ángel del Pozo, Satyajit Mayor, Marino Arroyo, Daniel Navajas, Xavier Trepat, Nils C. Gauthier () and Pere Roca-Cusachs ()
Additional contact information
Anita Joanna Kosmalska: Institute for Bioengineering of Catalonia (IBEC)
Laura Casares: Institute for Bioengineering of Catalonia (IBEC)
Alberto Elosegui-Artola: Institute for Bioengineering of Catalonia (IBEC)
Joseph Jose Thottacherry: National Centre for Biological Sciences (TIFR)
Roberto Moreno-Vicente: Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Víctor González-Tarragó: Institute for Bioengineering of Catalonia (IBEC)
Miguel Ángel del Pozo: Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Satyajit Mayor: National Centre for Biological Sciences (TIFR)
Marino Arroyo: LaCàN, Universitat Politècnica de Catalunya-BarcelonaTech
Daniel Navajas: Institute for Bioengineering of Catalonia (IBEC)
Xavier Trepat: Institute for Bioengineering of Catalonia (IBEC)
Nils C. Gauthier: Mechanobiology Institute, National University of Singapore
Pere Roca-Cusachs: Institute for Bioengineering of Catalonia (IBEC)

Nature Communications, 2015, vol. 6, issue 1, 1-11

Abstract: Abstract Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope—the bilayer membrane. However, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological perturbations can be explained by a purely mechanical process. This process is passive, local, almost instantaneous, before any active remodelling and generates different types of membrane invaginations that can repeatedly store and release large fractions of the cell membrane. We further demonstrate that the shape of those invaginations is determined by the minimum elastic and adhesive energy required to store both membrane area and liquid volume at the cell–substrate interface. Once formed, cells reabsorb the invaginations through an active process with duration of the order of minutes.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8292

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DOI: 10.1038/ncomms8292

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