Multiple independent autonomous hydraulic oscillators driven by a common gravity head

Sung-Jin Kim, Ryuji Yokokawa, Sasha Cai Lesher-Perez and Shuichi Takayama ()
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Sung-Jin Kim: Konkuk University
Ryuji Yokokawa: University of Michigan
Sasha Cai Lesher-Perez: University of Michigan
Shuichi Takayama: University of Michigan

Nature Communications, 2015, vol. 6, issue 1, 1-7

Abstract: Abstract Self-switching microfluidic circuits that are able to perform biochemical experiments in a parallel and autonomous manner, similar to instruction-embedded electronics, are rarely implemented. Here, we present design principles and demonstrations for gravity-driven, integrated, microfluidic pulsatile flow circuits. With a common gravity head as the only driving force, these fluidic oscillator arrays realize a wide range of periods (0.4 s–2 h) and flow rates (0.10–63 μl min−1) with completely independent timing between the multiple oscillator sub-circuits connected in parallel. As a model application, we perform systematic, parallel analysis of endothelial cell elongation response to different fluidic shearing patterns generated by the autonomous microfluidic pulsed flow generation system.

Date: 2015
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DOI: 10.1038/ncomms8301

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