Kumada–Grignard-type biaryl couplings on water

Anish Bhattacharjya, Piyatida Klumphu and Bruce H. Lipshutz ()
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Anish Bhattacharjya: University of California
Piyatida Klumphu: University of California
Bruce H. Lipshutz: University of California

Nature Communications, 2015, vol. 6, issue 1, 1-6

Abstract: Abstract Well-established, traditional Kumada cross-couplings involve preformed Grignard reagents in dry ethereal solvent that typically react, e.g., with aryl halides via Pd catalysis to afford products of net substitution. Therefore, in the work described, which appears to be counterintuitive, exposure of these same aromatic halides to catalytic amounts of Pd(II) and excess magnesium metal in pure water leads to symmetrical/unsymmetrical biaryls, indicative of a net Kumada-like biaryl coupling. Evidence is presented suggesting that Grignard reagents, formed in situ in water, may be involved.

Date: 2015
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DOI: 10.1038/ncomms8401

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