A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae

Jose Luis Ramirez, Giselle de Almeida Oliveira, Eric Calvo, Jesmond Dalli, Romain A. Colas, Charles N. Serhan, Jose M. Ribeiro and Carolina Barillas-Mury ()
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Jose Luis Ramirez: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Giselle de Almeida Oliveira: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Eric Calvo: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Jesmond Dalli: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative, and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School
Romain A. Colas: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative, and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School
Charles N. Serhan: Center for Experimental Therapeutics and Reperfusion Injury, Perioperative, and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School
Jose M. Ribeiro: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Carolina Barillas-Mury: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health

Nature Communications, 2015, vol. 6, issue 1, 1-7

Abstract: Abstract Exposure of Anopheles gambiae mosquitoes to Plasmodium infection enhances the ability of their immune system to respond to subsequent infections. However, the molecular mechanism that allows the insect innate immune system to ‘remember’ a previous encounter with a pathogen has not been established. Challenged mosquitoes constitutively release a soluble haemocyte differentiation factor into their haemolymph that, when transferred into Naive mosquitoes, also induces priming. Here we show that this factor consists of a Lipoxin/Lipocalin complex. We demonstrate that innate immune priming in mosquitoes involves a persistent increase in expression of Evokin (a lipid carrier of the lipocalin family), and in their ability to convert arachidonic acid to lipoxins, predominantly Lipoxin A4. Plasmodium ookinete midgut invasion triggers immune priming by inducing the release of a mosquito lipoxin/lipocalin complex.

Date: 2015
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DOI: 10.1038/ncomms8403

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