Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours

Tan A. Ince (), Aurea D. Sousa, Michelle A. Jones, J. Chuck Harrell, Elin S. Agoston, Marit Krohn, Laura M. Selfors, Wenbin Liu, Ken Chen, Mao Yong, Peter Buchwald, Bin Wang, Katherine S. Hale, Evan Cohick, Petra Sergent, Abigail Witt, Zhanna Kozhekbaeva, Sizhen Gao, Agoston T. Agoston, Melissa A. Merritt, Rosemary Foster, Bo R. Rueda, Christopher P. Crum, Joan S. Brugge and Gordon B. Mills
Additional contact information
Tan A. Ince: Interdisciplinary Stem Cell Institute, Braman Family Breast Cancer Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
Aurea D. Sousa: Interdisciplinary Stem Cell Institute, Braman Family Breast Cancer Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
Michelle A. Jones: Interdisciplinary Stem Cell Institute, Braman Family Breast Cancer Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
J. Chuck Harrell: Lineberger Comprehensive Cancer Center, University of North Carolina
Elin S. Agoston: Brigham and Women’s Hospital, Harvard Medical School
Marit Krohn: MD Anderson Cancer Center
Laura M. Selfors: Harvard Medical School
Wenbin Liu: MD Anderson Cancer Center
Ken Chen: MD Anderson Cancer Center
Mao Yong: MD Anderson Cancer Center
Peter Buchwald: University of Miami Miller School of Medicine
Bin Wang: Interdisciplinary Stem Cell Institute, Braman Family Breast Cancer Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
Katherine S. Hale: MD Anderson Cancer Center
Evan Cohick: Brigham and Women’s Hospital, Harvard Medical School
Petra Sergent: Vincent Center for Reproductive Biology, Massachusetts General Hospital and Harvard Medical School
Abigail Witt: Interdisciplinary Stem Cell Institute, Braman Family Breast Cancer Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
Zhanna Kozhekbaeva: Interdisciplinary Stem Cell Institute, Braman Family Breast Cancer Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
Sizhen Gao: Harvard Medical School
Agoston T. Agoston: Brigham and Women’s Hospital, Harvard Medical School
Melissa A. Merritt: Brigham and Women’s Hospital, Harvard Medical School
Rosemary Foster: Vincent Center for Reproductive Biology, Massachusetts General Hospital and Harvard Medical School
Bo R. Rueda: Vincent Center for Reproductive Biology, Massachusetts General Hospital and Harvard Medical School
Christopher P. Crum: Brigham and Women’s Hospital, Harvard Medical School
Joan S. Brugge: Harvard Medical School
Gordon B. Mills: MD Anderson Cancer Center

Nature Communications, 2015, vol. 6, issue 1, 1-14

Abstract: Abstract Currently available human tumour cell line panels consist of a small number of lines in each lineage that generally fail to retain the phenotype of the original patient tumour. Here we develop a cell culture medium that enables us to routinely establish cell lines from diverse subtypes of human ovarian cancers with >95% efficiency. Importantly, the 25 new ovarian tumour cell lines described here retain the genomic landscape, histopathology and molecular features of the original tumours. Furthermore, the molecular profile and drug response of these cell lines correlate with distinct groups of primary tumours with different outcomes. Thus, tumour cell lines derived using this methodology represent a significantly improved platform to study human tumour pathophysiology and response to therapy.

Date: 2015
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DOI: 10.1038/ncomms8419

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