Cidea improves the metabolic profile through expansion of adipose tissue

Gustavo Abreu-Vieira, Alexander W. Fischer, Charlotte Mattsson, Jasper M.A. de Jong, Irina G. Shabalina, Mikael Rydén, Jurga Laurencikiene, Peter Arner, Barbara Cannon, Jan Nedergaard and Natasa Petrovic ()
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Gustavo Abreu-Vieira: Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University
Alexander W. Fischer: Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University
Charlotte Mattsson: Karolinska Institutet
Jasper M.A. de Jong: Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University
Irina G. Shabalina: Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University
Mikael Rydén: Huddinge, Lipid Laboratory, Karolinska Institutet
Jurga Laurencikiene: Huddinge, Lipid Laboratory, Karolinska Institutet
Peter Arner: Huddinge, Lipid Laboratory, Karolinska Institutet
Barbara Cannon: Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University
Jan Nedergaard: Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University
Natasa Petrovic: Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University

Nature Communications, 2015, vol. 6, issue 1, 1-16

Abstract: Abstract In humans, Cidea (cell death-inducing DNA fragmentation factor alpha-like effector A) is highly but variably expressed in white fat, and expression correlates with metabolic health. Here we generate transgenic mice expressing human Cidea in adipose tissues (aP2-hCidea mice) and show that Cidea is mechanistically associated with a robust increase in adipose tissue expandability. Under humanized conditions (thermoneutrality, mature age and prolonged exposure to high-fat diet), aP2-hCidea mice develop a much more pronounced obesity than their wild-type littermates. Remarkably, the malfunctioning of visceral fat normally caused by massive obesity is fully overcome—perilipin 1 and Akt expression are preserved, tissue degradation is prevented, macrophage accumulation is decreased and adiponectin expression remains high. Importantly, the aP2-hCidea mice display enhanced insulin sensitivity. Our data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative.

Date: 2015
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DOI: 10.1038/ncomms8433

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