The immunomodulating V and W proteins of Nipah virus determine disease course

Benjamin A. Satterfield, Robert W. Cross, Karla A. Fenton, Krystle N. Agans, Christopher F. Basler, Thomas W. Geisbert () and Chad E. Mire
Additional contact information
Benjamin A. Satterfield: Galveston National Laboratory, University of Texas Medical Branch
Robert W. Cross: Galveston National Laboratory, University of Texas Medical Branch
Karla A. Fenton: Galveston National Laboratory, University of Texas Medical Branch
Krystle N. Agans: Galveston National Laboratory, University of Texas Medical Branch
Christopher F. Basler: Icahn School of Medicine at Mount Sinai
Thomas W. Geisbert: Galveston National Laboratory, University of Texas Medical Branch
Chad E. Mire: Galveston National Laboratory, University of Texas Medical Branch

Nature Communications, 2015, vol. 6, issue 1, 1-15

Abstract: Abstract The viral determinants that contribute to Nipah virus (NiV)-mediated disease are poorly understood compared with other paramyxoviruses. Here we use recombinant NiVs (rNiVs) to examine the contributions of the NiV V and W proteins to NiV pathogenesis in a ferret model. We show that a V-deficient rNiV is susceptible to the innate immune response in vitro and behaves as a replicating non-lethal virus in vivo. Remarkably, rNiV lacking W expression results in a delayed and altered disease course with decreased respiratory disease and increased terminal neurological disease associated with altered in vitro inflammatory cytokine production. This study confirms the V protein as the major determinant of pathogenesis, also being the first in vivo study to show that the W protein modulates the inflammatory host immune response in a manner that determines the disease course.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms8483 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8483

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms8483

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().