Exosomes released by keratinocytes modulate melanocyte pigmentation

Alessandra Lo Cicero, Cédric Delevoye, Floriane Gilles-Marsens, Damarys Loew, Florent Dingli, Christelle Guéré, Nathalie André, Katell Vié, Guillaume van Niel and Graça Raposo ()
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Alessandra Lo Cicero: Institut Curie, PSL Research University
Cédric Delevoye: Institut Curie, PSL Research University
Floriane Gilles-Marsens: Institut Curie, PSL Research University
Damarys Loew: Institut Curie, Centre de Recherche, Laboratoire de Spectrométrie de Masse Protéomique
Florent Dingli: Institut Curie, Centre de Recherche, Laboratoire de Spectrométrie de Masse Protéomique
Christelle Guéré: Laboratoires Clarins—31 chaussée Jules César
Nathalie André: Laboratoires Clarins—31 chaussée Jules César
Katell Vié: Laboratoires Clarins—31 chaussée Jules César
Guillaume van Niel: Institut Curie, PSL Research University
Graça Raposo: Institut Curie, PSL Research University

Nature Communications, 2015, vol. 6, issue 1, 1-8

Abstract: Abstract Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent and is modulated by ultraviolet B. In sum, this study uncovers an important physiological function for exosomes in human pigmentation and opens new avenues in our understanding of how pigmentation is regulated by intercellular communication in both healthy and diseased states.

Date: 2015
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DOI: 10.1038/ncomms8506

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