PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia

Tatsuro Nakamura, Shingo Maeda, Kazuhide Horiguchi, Toko Maehara, Kosuke Aritake, Byung-il Choi, Yoichiro Iwakura, Yoshihiro Urade and Takahisa Murata ()
Additional contact information
Tatsuro Nakamura: Graduate School of Agriculture and Life Sciences, The University of Tokyo
Shingo Maeda: Graduate School of Agriculture and Life Sciences, The University of Tokyo
Kazuhide Horiguchi: University of Fukui
Toko Maehara: Graduate School of Agriculture and Life Sciences, The University of Tokyo
Kosuke Aritake: International Institute for Integrative Sleep Medicine, University of Tsukuba
Byung-il Choi: College of Medicine, Korea University
Yoichiro Iwakura: Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science
Yoshihiro Urade: International Institute for Integrative Sleep Medicine, University of Tsukuba
Takahisa Murata: Graduate School of Agriculture and Life Sciences, The University of Tokyo

Nature Communications, 2015, vol. 6, issue 1, 1-10

Abstract: Abstract Prostaglandin D2 (PGD2) is a major prostanoid secreted mainly by mast cells. Although PGD2 has been identified as a modulator of allergic inflammation, its precise role remains unclear. Here we investigate the role of PGD2 in food allergy. Oral administration of ovalbumin induces allergic responses in sensitized wild-type (WT) mice. Systemic gene deficiency of haematopoietic PGD synthase (H-PGDS−/−) exacerbates all of the manifestations accompanying severe mast cell hyperplasia in the intestine. Morphological studies show that c-kit/FcɛRI-positive WT mast cells strongly express H-PGDS. Transplantation of H-PGDS−/− mast cells also aggravates ovalbumin-induced mast cell hyperplasia and allergic symptoms in mast cell null mice. H-PGDS deficiency accelerates the production of SDF-1α and the activity of MMP-9 in the antigen-stimulated intestine. SDF-1α receptor blockade or MMP-9 inhibition relieves the exacerbated mast cell hyperplasia and manifestations observed in H-PGDS−/−. Thus, PGD2 deficiency results in food antigen-induced mast cell hyperplasia.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms8514 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8514

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms8514

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().