Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells

Mélanie Chabaud, Mélina L. Heuzé, Marine Bretou, Pablo Vargas, Paolo Maiuri, Paola Solanes, Mathieu Maurin, Emmanuel Terriac, Maël Le Berre, Danielle Lankar, Tristan Piolot, Robert S. Adelstein, Yingfan Zhang, Michael Sixt, Jordan Jacobelli, Olivier Bénichou, Raphaël Voituriez, Matthieu Piel () and Ana-Maria Lennon-Duménil ()
Additional contact information
Mélanie Chabaud: Inserm U932, Institut Curie
Mélina L. Heuzé: Inserm U932, Institut Curie
Marine Bretou: Inserm U932, Institut Curie
Pablo Vargas: Inserm U932, Institut Curie
Paolo Maiuri: CNRS UMR144, Institut Curie
Paola Solanes: Inserm U932, Institut Curie
Mathieu Maurin: Inserm U932, Institut Curie
Emmanuel Terriac: CNRS UMR144, Institut Curie
Maël Le Berre: CNRS UMR144, Institut Curie
Danielle Lankar: Inserm U932, Institut Curie
Tristan Piolot: CNRS UMR3215/Inserm U934, Institut Curie
Robert S. Adelstein: Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health
Yingfan Zhang: Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health
Michael Sixt: Institute of Science and Technology Austria
Jordan Jacobelli: National Jewish Health & University of Colorado
Olivier Bénichou: CNRS UMR 7600, Université Pierre et Marie Curie
Raphaël Voituriez: CNRS UMR 7600, Université Pierre et Marie Curie
Matthieu Piel: CNRS UMR144, Institut Curie
Ana-Maria Lennon-Duménil: Inserm U932, Institut Curie

Nature Communications, 2015, vol. 6, issue 1, 1-16

Abstract: Abstract The immune response relies on the migration of leukocytes and on their ability to stop in precise anatomical locations to fulfil their task. How leukocyte migration and function are coordinated is unknown. Here we show that in immature dendritic cells, which patrol their environment by engulfing extracellular material, cell migration and antigen capture are antagonistic. This antagonism results from transient enrichment of myosin IIA at the cell front, which disrupts the back-to-front gradient of the motor protein, slowing down locomotion but promoting antigen capture. We further highlight that myosin IIA enrichment at the cell front requires the MHC class II-associated invariant chain (Ii). Thus, by controlling myosin IIA localization, Ii imposes on dendritic cells an intermittent antigen capture behaviour that might facilitate environment patrolling. We propose that the requirement for myosin II in both cell migration and specific cell functions may provide a general mechanism for their coordination in time and space.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8526

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DOI: 10.1038/ncomms8526

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