The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming

Liem Phan, Ping-Chieh Chou, Guermarie Velazquez-Torres, Ismael Samudio, Kenneth Parreno, Yaling Huang, Chieh Tseng, Thuy Vu, Chris Gully, Chun-Hui Su, Edward Wang, Jian Chen, Hyun-Ho Choi, Enrique Fuentes-Mattei, Ji-Hyun Shin, Christine Shiang, Brian Grabiner, Marzenna Blonska, Stephen Skerl, Yiping Shao, Dianna Cody, Jorge Delacerda, Charles Kingsley, Douglas Webb, Colin Carlock, Zhongguo Zhou, Yun-Chih Hsieh, Jaehyuk Lee, Andrew Elliott, Marc Ramirez, Jim Bankson, John Hazle, Yongxing Wang, Lei Li, Shaofan Weng, Nibal Rizk, Yu Ye Wen, Xin Lin, Hua Wang, Huamin Wang, Aijun Zhang, Xuefeng Xia, Yun Wu, Mouhammed Habra, Wei Yang, Lajos Pusztai, Sai-Ching Yeung and Mong-Hong Lee ()
Additional contact information
Liem Phan: The University of Texas MD Anderson Cancer Center
Ping-Chieh Chou: The University of Texas MD Anderson Cancer Center
Guermarie Velazquez-Torres: The University of Texas MD Anderson Cancer Center
Ismael Samudio: The University of Texas MD Anderson Cancer Center
Kenneth Parreno: The University of Texas MD Anderson Cancer Center
Yaling Huang: The University of Texas MD Anderson Cancer Center
Chieh Tseng: The University of Texas MD Anderson Cancer Center
Thuy Vu: The University of Texas MD Anderson Cancer Center
Chris Gully: The University of Texas MD Anderson Cancer Center
Chun-Hui Su: The University of Texas MD Anderson Cancer Center
Edward Wang: The University of Texas MD Anderson Cancer Center
Jian Chen: The University of Texas MD Anderson Cancer Center
Hyun-Ho Choi: The University of Texas MD Anderson Cancer Center
Enrique Fuentes-Mattei: The University of Texas MD Anderson Cancer Center
Ji-Hyun Shin: The University of Texas MD Anderson Cancer Center
Christine Shiang: Graduate School of Biomedical Sciences, The University of Texas at Houston
Brian Grabiner: The University of Texas MD Anderson Cancer Center
Marzenna Blonska: The University of Texas MD Anderson Cancer Center
Stephen Skerl: The University of Texas MD Anderson Cancer Center
Yiping Shao: The University of Texas MD Anderson Cancer Center
Dianna Cody: The University of Texas MD Anderson Cancer Center
Jorge Delacerda: The University of Texas MD Anderson Cancer Center
Charles Kingsley: The University of Texas MD Anderson Cancer Center
Douglas Webb: The University of Texas MD Anderson Cancer Center
Colin Carlock: The University of Texas MD Anderson Cancer Center
Zhongguo Zhou: The University of Texas MD Anderson Cancer Center
Yun-Chih Hsieh: The University of Texas MD Anderson Cancer Center
Jaehyuk Lee: The University of Texas MD Anderson Cancer Center
Andrew Elliott: The University of Texas MD Anderson Cancer Center
Marc Ramirez: The University of Texas MD Anderson Cancer Center
Jim Bankson: The University of Texas MD Anderson Cancer Center
John Hazle: The University of Texas MD Anderson Cancer Center
Yongxing Wang: The University of Texas MD Anderson Cancer Center
Lei Li: The University of Texas MD Anderson Cancer Center
Shaofan Weng: The University of Texas MD Anderson Cancer Center
Nibal Rizk: The University of Texas MD Anderson Cancer Center
Yu Ye Wen: The University of Texas MD Anderson Cancer Center
Xin Lin: The University of Texas MD Anderson Cancer Center
Hua Wang: The University of Texas MD Anderson Cancer Center
Huamin Wang: The University of Texas MD Anderson Cancer Center
Aijun Zhang: Methodist Hospital Research Institute
Xuefeng Xia: Methodist Hospital Research Institute
Yun Wu: The University of Texas MD Anderson Cancer Center
Mouhammed Habra: The University of Texas MD Anderson Cancer Center
Wei Yang: The University of Texas MD Anderson Cancer Center
Lajos Pusztai: The University of Texas MD Anderson Cancer Center
Sai-Ching Yeung: The University of Texas MD Anderson Cancer Center
Mong-Hong Lee: The University of Texas MD Anderson Cancer Center

Nature Communications, 2015, vol. 6, issue 1, 1-16

Abstract: Abstract Extensive reprogramming of cellular energy metabolism is a hallmark of cancer. Despite its importance, the molecular mechanism controlling this tumour metabolic shift remains not fully understood. Here we show that 14-3-3σ regulates cancer metabolic reprogramming and protects cells from tumorigenic transformation. 14-3-3σ opposes tumour-promoting metabolic programmes by enhancing c-Myc poly-ubiquitination and subsequent degradation. 14-3-3σ demonstrates the suppressive impact on cancer glycolysis, glutaminolysis, mitochondrial biogenesis and other major metabolic processes of tumours. Importantly, 14-3-3σ expression levels predict overall and recurrence-free survival rates, tumour glucose uptake and metabolic gene expression in breast cancer patients. Thus, these results highlight that 14-3-3σ is an important regulator of tumour metabolism, and loss of 14-3-3σ expression is critical for cancer metabolic reprogramming. We anticipate that pharmacologically elevating the function of 14-3-3σ in tumours could be a promising direction for targeted anticancer metabolism therapy development in future.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms8530 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8530

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms8530

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().