Large-scale genomics unveil polygenic architecture of human cortical surface area

Chi-Hua Chen (), Qian Peng, Andrew J. Schork, Min-Tzu Lo, Chun-Chieh Fan, Yunpeng Wang, Rahul S. Desikan, Francesco Bettella, Donald J. Hagler, Lars T. Westlye, William S. Kremen, Terry L. Jernigan, Stephanie Le Hellard, Vidar M. Steen, Thomas Espeseth, Matt Huentelman, Asta K. Håberg, Ingrid Agartz, Srdjan Djurovic, Ole A. Andreassen, Nicholas Schork () and Anders M. Dale ()
Additional contact information
Chi-Hua Chen: Multimodal Imaging Laboratory, University of California San Diego
Qian Peng: J. Craig Venter Institute
Andrew J. Schork: Multimodal Imaging Laboratory, University of California San Diego
Min-Tzu Lo: Multimodal Imaging Laboratory, University of California San Diego
Chun-Chieh Fan: Multimodal Imaging Laboratory, University of California San Diego
Yunpeng Wang: Multimodal Imaging Laboratory, University of California San Diego
Rahul S. Desikan: Multimodal Imaging Laboratory, University of California San Diego
Francesco Bettella: Norwegian Center for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo
Donald J. Hagler: Multimodal Imaging Laboratory, University of California San Diego
Lars T. Westlye: NORMENT, KG Jebsen Centre for Psychosis Research, University of Oslo
William S. Kremen: University of California, San Diego
Terry L. Jernigan: University of California, San Diego
Stephanie Le Hellard: Dr E. Martens Research Group of Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital
Vidar M. Steen: Dr E. Martens Research Group of Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital
Thomas Espeseth: NORMENT, KG Jebsen Centre for Psychosis Research, University of Oslo
Matt Huentelman: Translational Genomics Research Institute
Asta K. Håberg: Norwegian University of Science and Technology (NTNU)
Ingrid Agartz: Norwegian Center for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo
Srdjan Djurovic: NORMENT, KG Jebsen Centre for Psychosis Research, University of Bergen
Ole A. Andreassen: Norwegian Center for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo
Nicholas Schork: J. Craig Venter Institute
Anders M. Dale: Multimodal Imaging Laboratory, University of California San Diego

Nature Communications, 2015, vol. 6, issue 1, 1-7

Abstract: Abstract Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence brain morphology. Here, we examine brain imaging and single-nucleotide polymorphisms (SNPs) data from ∼2,700 individuals. We show that a substantial proportion of variation in cortical surface area is explained by additive effects of SNPs dispersed throughout the genome, with a larger heritable effect for visual and auditory sensory and insular cortices (h2∼0.45). Genome-wide SNPs collectively account for, on average, about half of twin heritability across cortical regions (N=466 twins). We find enriched genetic effects in or near genes. We also observe that SNPs in evolutionarily more conserved regions contributed significantly to the heritability of cortical surface area, particularly, for medial and temporal cortical regions. SNPs in less conserved regions contributed more to occipital and dorsolateral prefrontal cortices.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms8549 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8549

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms8549

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().