In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging

Zhenhua Hu, Yawei Qu, Kun Wang, Xiaojun Zhang, Jiali Zha, Tianming Song, Chengpeng Bao, Haixiao Liu, Zhongliang Wang, Jing Wang, Zhongyu Liu, Haifeng Liu () and Jie Tian ()
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Zhenhua Hu: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences
Yawei Qu: General Hospital of Chinese People’s Armed Police Forces
Kun Wang: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences
Xiaojun Zhang: Chinese PLA General Hospital
Jiali Zha: General Hospital of Chinese People’s Armed Police Forces
Tianming Song: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences
Chengpeng Bao: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences
Haixiao Liu: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences
Zhongliang Wang: School of Life Science and Technology, Xidian University
Jing Wang: Xijing Hospital, Fourth Military Medical University
Zhongyu Liu: Anal-colorectal Surgery Institute, No. 150 Central Hospital of PLA
Haifeng Liu: General Hospital of Chinese People’s Armed Police Forces
Jie Tian: Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences

Nature Communications, 2015, vol. 6, issue 1, 1-12

Abstract: Abstract Cerenkov luminescence imaging utilizes visible photons emitted from radiopharmaceuticals to achieve in vivo optical molecular-derived signals. Since Cerenkov radiation is weak, non-optimum for tissue penetration and continuous regardless of biological interactions, it is challenging to detect this signal with a diagnostic dose. Therefore, it is challenging to achieve useful activated optical imaging for the acquisition of direct molecular information. Here we introduce a novel imaging strategy, which converts γ and Cerenkov radiation from radioisotopes into fluorescence through europium oxide nanoparticles. After a series of imaging studies, we demonstrate that this approach provides strong optical signals with high signal-to-background ratios, an ideal tissue penetration spectrum and activatable imaging ability. In comparison with present imaging techniques, it detects tumour lesions with low radioactive tracer uptake or small tumour lesions more effectively. We believe it will facilitate the development of nuclear and optical molecular imaging for new, highly sensitive imaging applications.

Date: 2015
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DOI: 10.1038/ncomms8560

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