Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis

Eric Linster, Iwona Stephan, Willy V. Bienvenut, Jodi Maple-Grødem, Line M. Myklebust, Monika Huber, Michael Reichelt, Carsten Sticht, Simon Geir Møller, Thierry Meinnel, Thomas Arnesen, Carmela Giglione, Rüdiger Hell and Markus Wirtz ()
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Eric Linster: Centre for Organismal Studies, University of Heidelberg
Iwona Stephan: Centre for Organismal Studies, University of Heidelberg
Willy V. Bienvenut: Institute of Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud
Jodi Maple-Grødem: Center for Organelle Research, University of Stavanger
Line M. Myklebust: University of Bergen
Monika Huber: Centre for Organismal Studies, University of Heidelberg
Michael Reichelt: Max Planck institute for Chemical Ecology
Carsten Sticht: Center for Medical Research
Simon Geir Møller: Center for Organelle Research, University of Stavanger
Thierry Meinnel: Institute of Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud
Thomas Arnesen: University of Bergen
Carmela Giglione: Institute of Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud
Rüdiger Hell: Centre for Organismal Studies, University of Heidelberg
Markus Wirtz: Centre for Organismal Studies, University of Heidelberg

Nature Communications, 2015, vol. 6, issue 1, 1-13

Abstract: Abstract N-terminal acetylation (NTA) catalysed by N-terminal acetyltransferases (Nats) is among the most common protein modifications in eukaryotes, but its significance is still enigmatic. Here we characterize the plant NatA complex and reveal evolutionary conservation of NatA biochemical properties in higher eukaryotes and uncover specific and essential functions of NatA for development, biosynthetic pathways and stress responses in plants. We show that NTA decreases significantly after drought stress, and NatA abundance is rapidly downregulated by the phytohormone abscisic acid. Accordingly, transgenic downregulation of NatA induces the drought stress response and results in strikingly drought resistant plants. Thus, we propose that NTA by the NatA complex acts as a cellular surveillance mechanism during stress and that imprinting of the proteome by NatA is an important switch for the control of metabolism, development and cellular stress responses downstream of abscisic acid.

Date: 2015
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DOI: 10.1038/ncomms8640

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