A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking

Yi-xiao Luo, Yan-xue Xue, Jian-feng Liu, Hai-shui Shi, Min Jian, Ying Han, Wei-li Zhu, Yan-ping Bao, Ping Wu, Zeng-bo Ding, Hao-wei Shen, Jie Shi, Yavin Shaham and Lin Lu ()
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Yi-xiao Luo: Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University
Yan-xue Xue: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University
Jian-feng Liu: Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University
Hai-shui Shi: Basic Medical College, Hebei Medical University
Min Jian: Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University
Ying Han: Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University
Wei-li Zhu: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University
Yan-ping Bao: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University
Ping Wu: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University
Zeng-bo Ding: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University
Hao-wei Shen: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University
Jie Shi: National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University
Yavin Shaham: Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health
Lin Lu: Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University

Nature Communications, 2015, vol. 6, issue 1, 1-14

Abstract: Abstract We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts.

Date: 2015
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DOI: 10.1038/ncomms8675

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