Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2

Yue Zhou, Naoki Yamada, Tomohiro Tanaka, Takashi Hori, Satoru Yokoyama, Yoshihiro Hayakawa, Seiji Yano, Junya Fukuoka, Keiichi Koizumi, Ikuo Saiki and Hiroaki Sakurai ()
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Yue Zhou: Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Naoki Yamada: Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Tomohiro Tanaka: Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Takashi Hori: Toyama University Hospital
Satoru Yokoyama: Institute of Natural Medicine, University of Toyama
Yoshihiro Hayakawa: Institute of Natural Medicine, University of Toyama
Seiji Yano: Cancer Research Institute, Kanazawa University
Junya Fukuoka: Nagasaki University Graduate School of Biomedical Sciences
Keiichi Koizumi: Institute of Natural Medicine, University of Toyama
Ikuo Saiki: Institute of Natural Medicine, University of Toyama
Hiroaki Sakurai: Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

Nature Communications, 2015, vol. 6, issue 1, 1-12

Abstract: Abstract Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has been revealed as an indicator of cancer malignant progression. In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. It has been reported that ligand-independent phosphorylation of EphA2 at Ser-897 is induced by Akt. We show that inflammatory cytokines promote RSK-, not Akt-, dependent phosphorylation of EphA2 at Ser-897. In addition, the RSK–EphA2 signalling pathway controls cell migration and invasion of metastatic breast cancer cells. Moreover, Ser-897-phosphorylated EphA2 co-localizes with phosphorylated active form of RSK in various human tumour specimens, and this double positivity is related to poor survival in lung cancer patients, especially those with a smoking history. Taken together, these results indicate that the phosphorylation of EphA2 at Ser-897 is controlled by RSK and the RSK–EphA2 axis might contribute to cell motility and promote tumour malignant progression.

Date: 2015
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DOI: 10.1038/ncomms8679

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