Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery

Charles Robb Flynn, Vance L. Albaugh, Steven Cai, Joyce Cheung-Flynn, Phillip E. Williams, Robert M. Brucker, Seth R. Bordenstein, Yan Guo, David H. Wasserman and Naji N. Abumrad ()
Additional contact information
Charles Robb Flynn: Vanderbilt University Medical Center, 1161 21st Avenue South, MCN CC2308, Nashville, Tennessee 37232-2730, USA.
Vance L. Albaugh: Vanderbilt University Medical Center, 1161 21st Avenue South, MCN CC2308, Nashville, Tennessee 37232-2730, USA.
Steven Cai: Rosalind Franklin University
Joyce Cheung-Flynn: Vanderbilt University Medical Center, 1161 21st Avenue South, MCN CC2308, Nashville, Tennessee 37232-2730, USA.
Phillip E. Williams: Vanderbilt University Medical Center, 1161 21st Avenue South, MCN CC2308, Nashville, Tennessee 37232-2730, USA.
Robert M. Brucker: Vanderbilt University
Seth R. Bordenstein: Vanderbilt University
Yan Guo: Center for Quantitative Sciences, Vanderbilt University
David H. Wasserman: Vanderbilt University Medical Center
Naji N. Abumrad: Vanderbilt University Medical Center, 1161 21st Avenue South, MCN CC2308, Nashville, Tennessee 37232-2730, USA.

Nature Communications, 2015, vol. 6, issue 1, 1-14

Abstract: Abstract Roux-en-Y gastric bypass (RYGB) is highly effective in reversing obesity and associated diabetes. Recent observations in humans suggest a contributing role of increased circulating bile acids in mediating such effects. Here we use a diet-induced obesity (DIO) mouse model and compare metabolic remission when bile flow is diverted through a gallbladder anastomosis to jejunum, ileum or duodenum (sham control). We find that only bile diversion to the ileum results in physiologic changes similar to RYGB, including sustained improvements in weight, glucose tolerance and hepatic steatosis despite differential effects on hepatic gene expression. Circulating free fatty acids and triglycerides decrease while bile acids increase, particularly conjugated tauro-β-muricholic acid, an FXR antagonist. Activity of the hepatic FXR/FGF15 signalling axis is reduced and associated with altered gut microbiota. Thus bile diversion, independent of surgical rearrangement of the gastrointestinal tract, imparts significant weight loss accompanied by improved glucose and lipid homeostasis that are hallmarks of RYGB.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms8715 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8715

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms8715

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().