The key role of the scaffold on the efficiency of dendrimer nanodrugs

Anne-Marie Caminade (), Séverine Fruchon, Cédric-Olivier Turrin, Mary Poupot, Armelle Ouali, Alexandrine Maraval, Matteo Garzoni, Marek Maly, Victor Furer, Valeri Kovalenko, Jean-Pierre Majoral, Giovanni M. Pavan () and Rémy Poupot ()
Additional contact information
Anne-Marie Caminade: Laboratoire de Chimie de Coordination du CNRS
Séverine Fruchon: Centre de Physiopathologie de Toulouse Purpan
Cédric-Olivier Turrin: Laboratoire de Chimie de Coordination du CNRS
Mary Poupot: Centre de Recherche en Cancérologie de Toulouse
Armelle Ouali: Laboratoire de Chimie de Coordination du CNRS
Alexandrine Maraval: Laboratoire de Chimie de Coordination du CNRS
Matteo Garzoni: University of Applied Sciences and Arts of Southern Switzerland
Marek Maly: Faculty of Science, J.E. Purkinje University
Victor Furer: Kazan State Architect and Civil Engineering University
Valeri Kovalenko: A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Science
Jean-Pierre Majoral: Laboratoire de Chimie de Coordination du CNRS
Giovanni M. Pavan: University of Applied Sciences and Arts of Southern Switzerland
Rémy Poupot: Centre de Physiopathologie de Toulouse Purpan

Nature Communications, 2015, vol. 6, issue 1, 1-11

Abstract: Abstract Dendrimers are well-defined macromolecules whose highly branched structure is reminiscent of many natural structures, such as trees, dendritic cells, neurons or the networks of kidneys and lungs. Nature has privileged such branched structures for increasing the efficiency of exchanges with the external medium; thus, the whole structure is of pivotal importance for these natural networks. On the contrary, it is generally believed that the properties of dendrimers are essentially related to their terminal groups, and that the internal structure plays the minor role of an ‘innocent’ scaffold. Here we show that such an assertion is misleading, using convergent information from biological data (human monocytes activation) and all-atom molecular dynamics simulations on seven families of dendrimers (13 compounds) that we have synthesized, possessing identical terminal groups, but different internal structures. This work demonstrates that the scaffold of nanodrugs strongly influences their properties, somewhat reminiscent of the backbone of proteins.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms8722 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8722

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms8722

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().