Parallel circuits control temperature preference in Drosophila during ageing

Hsiang-Wen Shih, Chia-Lin Wu (), Sue-Wei Chang, Tsung-Ho Liu, Jason Sih-Yu Lai, Tsai-Feng Fu, Chien-Chung Fu and Ann-Shyn Chiang ()
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Hsiang-Wen Shih: Institute of Biotechnology, National Tsing Hua University
Chia-Lin Wu: College of Medicine, Chang Gung University
Sue-Wei Chang: National Tsing Hua University
Tsung-Ho Liu: National Tsing Hua University
Jason Sih-Yu Lai: Institute of Biotechnology, National Tsing Hua University
Tsai-Feng Fu: National Chi Nan University
Chien-Chung Fu: National Tsing Hua University
Ann-Shyn Chiang: Institute of Biotechnology, National Tsing Hua University

Nature Communications, 2015, vol. 6, issue 1, 1-9

Abstract: Abstract The detection of environmental temperature and regulation of body temperature are integral determinants of behaviour for all animals. These functions become less efficient in aged animals, particularly during exposure to cold environments, yet the cellular and molecular mechanisms are not well understood. Here, we identify an age-related change in the temperature preference of adult fruit flies that results from a shift in the relative contributions of two parallel mushroom body (MB) circuits—the β′- and β-systems. The β′-circuit primarily controls cold avoidance through dopamine signalling in young flies, whereas the β-circuit increasingly contributes to cold avoidance as adult flies age. Elevating dopamine levels in β′-afferent neurons of aged flies restores cold sensitivity, suggesting that the alteration of cold avoidance behaviour with ageing is functionally reversible. These results provide a framework for investigating how molecules and individual neural circuits modulate homeostatic alterations during the course of senescence.

Date: 2015
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DOI: 10.1038/ncomms8775

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