Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model

Eric M. Brown, Marta Wlodarska, Benjamin P. Willing, Pascale Vonaesch, Jun Han, Lisa A. Reynolds, Marie-Claire Arrieta, Marco Uhrig, Roland Scholz, Oswaldo Partida, Christoph H. Borchers, Philippe J. Sansonetti and B. Brett Finlay ()
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Eric M. Brown: University of British Columbia
Marta Wlodarska: University of British Columbia
Benjamin P. Willing: Food and Nutritional Science, University of Alberta
Pascale Vonaesch: Molecular Microbial Pathogenesis Unit, Institut Pasteur
Jun Han: The UVic-Genome British Columbia Proteomics Centre, University of Victoria
Lisa A. Reynolds: Michael Smith Laboratories, University of British Columbia
Marie-Claire Arrieta: Michael Smith Laboratories, University of British Columbia
Marco Uhrig: University of British Columbia
Roland Scholz: Michael Smith Laboratories, University of British Columbia
Oswaldo Partida: Michael Smith Laboratories, University of British Columbia
Christoph H. Borchers: The UVic-Genome British Columbia Proteomics Centre, University of Victoria
Philippe J. Sansonetti: Molecular Microbial Pathogenesis Unit, Institut Pasteur
B. Brett Finlay: University of British Columbia

Nature Communications, 2015, vol. 6, issue 1, 1-16

Abstract: Abstract Environmental enteropathy (EE) is a subclinical chronic inflammatory disease of the small intestine and has a profound impact on the persistence of childhood malnutrition worldwide. However, the aetiology of the disease remains unknown and no animal model exists to date, the creation of which would aid in understanding this complex disease. Here we demonstrate that early-life consumption of a moderately malnourished diet, in combination with iterative oral exposure to commensal Bacteroidales species and Escherichia coli, remodels the murine small intestine to resemble features of EE observed in humans. We further report the profound changes that malnutrition imparts on the small intestinal microbiota, metabolite and intraepithelial lymphocyte composition, along with the susceptibility to enteric infection. Our findings provide evidence indicating that both diet and microbes combine to contribute to the aetiology of EE, and describe a novel murine model that can be used to elucidate the mechanisms behind this understudied disease.

Date: 2015
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DOI: 10.1038/ncomms8806

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