An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis

Sylvain Meunier, Maria Shvedunova, Nhuong Van Nguyen, Leonor Avila, Isabelle Vernos () and Asifa Akhtar ()
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Sylvain Meunier: Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG)
Maria Shvedunova: Max Planck Institute of Immunobiology and Epigenetics
Nhuong Van Nguyen: Max Planck Institute of Immunobiology and Epigenetics
Leonor Avila: Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG)
Isabelle Vernos: Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG)
Asifa Akhtar: Max Planck Institute of Immunobiology and Epigenetics

Nature Communications, 2015, vol. 6, issue 1, 1-10

Abstract: Abstract The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minus-end-binding protein, revealing a new class of mitosis-specific microtubule minus-end regulators. By adopting distinct functions in interphase and mitosis, KANSL proteins provide a link to coordinate the tasks of faithful expression and inheritance of the genome during different phases of the cell cycle.

Date: 2015
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DOI: 10.1038/ncomms8889

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