Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study

G. Paul Amminger (), Miriam R. Schäfer, Monika Schlögelhofer, Claudia M. Klier and Patrick D. McGorry
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G. Paul Amminger: Orygen—The National Centre of Excellence in Youth Mental Health, The University of Melbourne
Miriam R. Schäfer: Orygen—The National Centre of Excellence in Youth Mental Health, The University of Melbourne
Monika Schlögelhofer: Medical University of Vienna
Claudia M. Klier: Medical University of Vienna
Patrick D. McGorry: Orygen—The National Centre of Excellence in Youth Mental Health, The University of Melbourne

Nature Communications, 2015, vol. 6, issue 1, 1-7

Abstract: Abstract Long-chain omega-3 polyunsaturated fatty acids (PUFAs) are essential for neural development and function. As key components of brain tissue, omega-3 PUFAs play critical roles in brain development and function, and a lack of these fatty acids has been implicated in a number of mental health conditions over the lifespan, including schizophrenia. We have previously shown that a 12-week intervention with omega-3 PUFAs reduced the risk of progression to psychotic disorder in young people with subthreshold psychotic states for a 12-month period compared with placebo. We have now completed a longer-term follow-up of this randomized, double-blind, placebo-controlled trial, at a median of 6.7 years. Here we show that brief intervention with omega-3 PUFAs reduced both the risk of progression to psychotic disorder and psychiatric morbidity in general in this study. The majority of the individuals from the omega-3 group did not show severe functional impairment and no longer experienced attenuated psychotic symptoms at follow-up.

Date: 2015
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DOI: 10.1038/ncomms8934

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