Batf is important for IL-4 expression in T follicular helper cells

Anupama Sahoo, Andrei Alekseev, Kentaro Tanaka, Lidiya Obertas, Beatrisa Lerman, Cara Haymaker, Karen Clise-Dwyer, John S. McMurray and Roza Nurieva ()
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Anupama Sahoo: MD Anderson Cancer Center
Andrei Alekseev: MD Anderson Cancer Center
Kentaro Tanaka: MD Anderson Cancer Center
Lidiya Obertas: MD Anderson Cancer Center
Beatrisa Lerman: MD Anderson Cancer Center
Cara Haymaker: MD Anderson Cancer Center
Karen Clise-Dwyer: MD Anderson Cancer Center
John S. McMurray: MD Anderson Cancer Center
Roza Nurieva: MD Anderson Cancer Center

Nature Communications, 2015, vol. 6, issue 1, 1-10

Abstract: Abstract Apart from T helper (Th)-2 cells, T follicular helper (Tfh) cells are a major class of IL-4-producing T cells, required for regulation of type 2 humoral immunity; however, transcriptional control of IL-4 production in Tfh cells remains mainly unknown. Here, we show that the basic leucine zipper transcription factor ATF-like, Batf is important for IL-4 expression in Tfh cells rather than in canonical Th2 cells. Functionally, Batf in cooperation with interferon regulatory factor (IRF) 4 along with Stat3 and Stat6 trigger IL-4 production in Tfh cells by directly binding to and activation of the CNS2 region in the IL-4 locus. In addition, Batf-to-c-Maf signalling is an important determinant of IL-4 expression in Tfh cells. Batf deficiency impairs the generation of IL-4-producing Tfh cells that results in protection against allergic asthma. Our results thus indicate a positive role of Batf in promoting the generation of pro-allergic IL-4-producing Tfh cells.

Date: 2015
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DOI: 10.1038/ncomms8997

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