Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting

Munitta Muthana (), Aneurin J. Kennerley, Russell Hughes, Ester Fagnano, Jay Richardson, Melanie Paul, Craig Murdoch, Fiona Wright, Christopher Payne, Mark F. Lythgoe, Neil Farrow, Jon Dobson, Joe Conner, Jim M. Wild and Claire Lewis
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Munitta Muthana: University of Sheffield
Aneurin J. Kennerley: University of Sheffield
Russell Hughes: University of Sheffield
Ester Fagnano: University of Sheffield
Jay Richardson: University of Sheffield
Melanie Paul: University of Sheffield
Craig Murdoch: Unit of Oral & Maxillofacial Medicine & Surgery, University of Sheffield
Fiona Wright: University of Sheffield
Christopher Payne: Centre for Advanced Biomedical Imaging, University College London
Mark F. Lythgoe: Centre for Advanced Biomedical Imaging, University College London
Neil Farrow: Institute for Science and Technology in Medicine, Keele University
Jon Dobson: University of Florida
Joe Conner: Virttu Biologics, Glasgow
Jim M. Wild: Cardiovascular Sciences, University of Sheffield
Claire Lewis: University of Sheffield

Nature Communications, 2015, vol. 6, issue 1, 1-11

Abstract: Abstract Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic virus, Seprehvir, into primary and metastatic tumour sites in mice. To achieve this, we magnetically label macrophages with super-paramagnetic iron oxide nanoparticles and apply pulsed magnetic field gradients in the direction of the tumour sites. Magnetic resonance targeting guides macrophages from the bloodstream into tumours, resulting in increased tumour macrophage infiltration and reduction in tumour burden and metastasis. Our study indicates that clinical MRI scanners can not only track the location of magnetically labelled cells but also have the potential to steer them into one or more target tissues.

Date: 2015
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DOI: 10.1038/ncomms9009

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