Refining the pathway of carbide insertion into the nitrogenase M-cluster

Jared A. Wiig, Yilin Hu () and Markus W. Ribbe ()
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Jared A. Wiig: University of California
Yilin Hu: University of California
Markus W. Ribbe: University of California

Nature Communications, 2015, vol. 6, issue 1, 1-6

Abstract: Abstract Carbide insertion plays a pivotal role in the biosynthesis of M-cluster, the cofactor of nitrogenase. Previously, we proposed a carbide insertion pathway involving methyltransfer from SAM to a FeS precursor and hydrogen abstraction from this methyl group that initiates the radical-based precursor maturation. Here we demonstrate that the methyl group is transferred to a precursor-associated sulfur before hydrogen abstraction, thereby refining the initial steps of the carbide insertion pathway.

Date: 2015
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DOI: 10.1038/ncomms9034

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