Association analysis identifies new risk loci for congenital heart disease in Chinese populations

Yuan Lin, Xuejiang Guo, Bijun Zhao, Juanjuan Liu, Min Da, Yang Wen, Yuanli Hu, Bixian Ni, Kai Zhang, Shiwei Yang, Jing Xu, Juncheng Dai, Xiaowei Wang, Yankai Xia, Hongxia Ma, Guangfu Jin, Shiqiang Yu, Jiayin Liu, Bernard D. Keavney, Judith A. Goodship, Heather J. Cordell, Xinru Wang, Hongbing Shen, Jiahao Sha, Zuomin Zhou, Yijiang Chen, Xuming Mo (), Lingfei Luo () and Zhibin Hu ()
Additional contact information
Yuan Lin: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Xuejiang Guo: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Bijun Zhao: Xijing hospital, The Fourth Military Medical University
Juanjuan Liu: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Min Da: Nanjing Children's Hospital, Nanjing Medical University
Yang Wen: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Yuanli Hu: Nanjing Children's Hospital, Nanjing Medical University
Bixian Ni: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Kai Zhang: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Shiwei Yang: Nanjing Children's Hospital, Nanjing Medical University
Jing Xu: The First Affiliated Hospital of Nanjing Medical University
Juncheng Dai: School of Public Health, Nanjing Medical University
Xiaowei Wang: The First Affiliated Hospital of Nanjing Medical University
Yankai Xia: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Hongxia Ma: School of Public Health, Nanjing Medical University
Guangfu Jin: School of Public Health, Nanjing Medical University
Shiqiang Yu: Xijing hospital, The Fourth Military Medical University
Jiayin Liu: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Bernard D. Keavney: Institute of Genetic Medicine, Newcastle University
Judith A. Goodship: Institute of Genetic Medicine, Newcastle University
Heather J. Cordell: Institute of Genetic Medicine, Newcastle University
Xinru Wang: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Hongbing Shen: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Jiahao Sha: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Zuomin Zhou: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Yijiang Chen: The First Affiliated Hospital of Nanjing Medical University
Xuming Mo: Nanjing Children's Hospital, Nanjing Medical University
Lingfei Luo: Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Laboratory of Molecular Developmental Biology, School of Life Sciences, Southwest University
Zhibin Hu: State Key Laboratory of Reproductive Medicine, Nanjing Medical University

Nature Communications, 2015, vol. 6, issue 1, 1-7

Abstract: Abstract Our previous genome-wide association study (GWAS) identified two susceptibility loci for congenital heart disease (CHD) in Han Chinese. Here we identify additional loci by testing promising associations in an extended 3-stage validation consisting of 6,053 CHD cases and 7,410 controls. We find GW significant (P

Date: 2015
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DOI: 10.1038/ncomms9082

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