Sliding tethered ligands add topological interactions to the toolbox of ligand–receptor design

Martin Bauer, Patrick Kékicheff, Jean Iss, Christophe Fajolles, Thierry Charitat, Jean Daillant and Carlos M. Marques ()
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Martin Bauer: Institut Charles Sadron, Université de Strasbourg, CNRS-UPR 22
Patrick Kékicheff: Institut Charles Sadron, Université de Strasbourg, CNRS-UPR 22
Jean Iss: Institut Charles Sadron, Université de Strasbourg, CNRS-UPR 22
Christophe Fajolles: CEA/ IRAMIS/SIS2M/LIONS, UMR 3299 CEA/CNRS
Thierry Charitat: Institut Charles Sadron, Université de Strasbourg, CNRS-UPR 22
Jean Daillant: CEA/ IRAMIS/SIS2M/LIONS, UMR 3299 CEA/CNRS
Carlos M. Marques: Institut Charles Sadron, Université de Strasbourg, CNRS-UPR 22

Nature Communications, 2015, vol. 6, issue 1, 1-8

Abstract: Abstract Adhesion in the biological realm is mediated by specific lock-and-key interactions between ligand–receptor pairs. These complementary moieties are ubiquitously anchored to substrates by tethers that control the interaction range and the mobility of the ligands and receptors, thus tuning the kinetics and strength of the binding events. Here we add sliding anchoring to the toolbox of ligand–receptor design by developing a family of tethered ligands for which the spacer can slide at the anchoring point. Our results show that this additional sliding degree of freedom changes the nature of the adhesive contact by extending the spatial range over which binding may sustain a significant force. By introducing sliding tethered ligands with self-regulating length, this work paves the way for the development of versatile and reusable bio-adhesive substrates with potential applications for drug delivery and tissue engineering.

Date: 2015
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DOI: 10.1038/ncomms9117

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