Telomere maintenance through recruitment of internal genomic regions

Beomseok Seo, Chuna Kim, Mark Hills, Sanghyun Sung, Hyesook Kim, Eunkyeong Kim, Daisy S. Lim, Hyun-Seok Oh, Rachael Mi Jung Choi, Jongsik Chun, Jaegal Shim and Junho Lee ()
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Beomseok Seo: Institute of Molecular Biology and Genetics, Seoul National University
Chuna Kim: Institute of Molecular Biology and Genetics, Seoul National University
Mark Hills: Terry Fox Laboratory, BC Cancer Agency
Sanghyun Sung: Institute of Molecular Biology and Genetics, Seoul National University
Hyesook Kim: Institute of Molecular Biology and Genetics, Seoul National University
Eunkyeong Kim: Institute of Molecular Biology and Genetics, Seoul National University
Daisy S. Lim: Institute of Molecular Biology and Genetics, Seoul National University
Hyun-Seok Oh: Bioinformatics Institute, BIO-MAX, Seoul National University
Rachael Mi Jung Choi: Bioinformatics Institute, BIO-MAX, Seoul National University
Jongsik Chun: Bioinformatics Institute, BIO-MAX, Seoul National University
Jaegal Shim: Research Institute, National Cancer Center
Junho Lee: Institute of Molecular Biology and Genetics, Seoul National University

Nature Communications, 2015, vol. 6, issue 1, 1-10

Abstract: Abstract Cells surviving crisis are often tumorigenic and their telomeres are commonly maintained through the reactivation of telomerase. However, surviving cells occasionally activate a recombination-based mechanism called alternative lengthening of telomeres (ALT). Here we establish stably maintained survivors in telomerase-deleted Caenorhabditis elegans that escape from sterility by activating ALT. ALT survivors trans-duplicate an internal genomic region, which is already cis-duplicated to chromosome ends, across the telomeres of all chromosomes. These ‘Template for ALT’ (TALT) regions consist of a block of genomic DNA flanked by telomere-like sequences, and are different between two genetic background. We establish a model that an ancestral duplication of a donor TALT region to a proximal telomere region forms a genomic reservoir ready to be incorporated into telomeres on ALT activation.

Date: 2015
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DOI: 10.1038/ncomms9189

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