Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Kate Lawrenson, Qiyuan Li, Siddhartha Kar, Ji-Heui Seo, Jonathan Tyrer, Tassja J. Spindler, Janet Lee, Yibu Chen, Alison Karst, Ronny Drapkin, Katja K. H. Aben, Hoda Anton-Culver, Natalia Antonenkova, Helen Baker, Elisa V. Bandera, Yukie Bean, Matthias W. Beckmann, Andrew Berchuck, Maria Bisogna, Line Bjorge, Natalia Bogdanova, Louise A. Brinton, Angela Brooks-Wilson, Fiona Bruinsma, Ralf Butzow, Ian G. Campbell, Karen Carty, Jenny Chang-Claude, Georgia Chenevix-Trench, Anne Chen, Zhihua Chen, Linda S. Cook, Daniel W. Cramer, Julie M. Cunningham, Cezary Cybulski, Agnieszka Dansonka-Mieszkowska, Joe Dennis, Ed Dicks, Jennifer A. Doherty, Thilo Dörk, Andreas du Bois, Matthias Dürst, Diana Eccles, Douglas T. Easton, Robert P. Edwards, Ursula Eilber, Arif B. Ekici, Peter A. Fasching, Brooke L. Fridley, Yu-Tang Gao, Aleksandra Gentry-Maharaj, Graham G. Giles, Rosalind Glasspool, Ellen L. Goode, Marc T. Goodman, Jacek Grownwald, Patricia Harrington, Philipp Harter, Hanis Nazihah Hasmad, Alexander Hein, Florian Heitz, Michelle A. T. Hildebrandt, Peter Hillemanns, Estrid Hogdall, Claus Hogdall, Satoyo Hosono, Edwin S. Iversen, Anna Jakubowska, Paul James, Allan Jensen, Bu-Tian Ji, Beth Y. Karlan, Susanne Kruger Kjaer, Linda E. Kelemen, Melissa Kellar, Joseph L. Kelley, Lambertus A. Kiemeney, Camilla Krakstad, Jolanta Kupryjanczyk, Diether Lambrechts, Sandrina Lambrechts, Nhu D. Le, Alice W. Lee, Shashi Lele, Arto Leminen, Jenny Lester, Douglas A. Levine, Dong Liang, Jolanta Lissowska, Karen Lu, Jan Lubinski, Lene Lundvall, Leon F. A. G. Massuger, Keitaro Matsuo, Valerie McGuire, John R. McLaughlin, Heli Nevanlinna, Ian McNeish, Usha Menon, Francesmary Modugno, Kirsten B. Moysich, Steven A. Narod, Lotte Nedergaard, Roberta B. Ness, Mat Adenan Noor Azmi, Kunle Odunsi, Sara H. Olson, Irene Orlow, Sandra Orsulic, Rachel Palmieri Weber, Celeste L. Pearce, Tanja Pejovic, Liisa M. Pelttari, Jennifer Permuth-Wey, Catherine M. Phelan, Malcolm C. Pike, Elizabeth M. Poole, Susan J. Ramus, Harvey A. Risch, Barry Rosen, Mary Anne Rossing, Joseph H. Rothstein, Anja Rudolph, Ingo B. Runnebaum, Iwona K. Rzepecka, Helga B. Salvesen, Joellen M. Schildkraut, Ira Schwaab, Thomas A. Sellers, Xiao-Ou Shu, Yurii B. Shvetsov, Nadeem Siddiqui, Weiva Sieh, Honglin Song, Melissa C. Southey, Lara Sucheston, Ingvild L. Tangen, Soo-Hwang Teo, Kathryn L. Terry, Pamela J. Thompson, Agnieszka Timorek, Ya-Yu Tsai, Shelley S. Tworoger, Anne M. van Altena, Els Van Nieuwenhuysen, Ignace Vergote, Robert A. Vierkant, Shan Wang-Gohrke, Christine Walsh, Nicolas Wentzensen, Alice S. Whittemore, Kristine G. Wicklund, Lynne R. Wilkens, Yin-Ling Woo, Xifeng Wu, Anna H. Wu, Hannah Yang, Wei Zheng, Argyrios Ziogas, Alvaro Monteiro, Paul D. Pharoah, Simon A. Gayther () and Matthew L. Freedman
Additional contact information
Kate Lawrenson: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Qiyuan Li: Medical College, Xiamen University
Siddhartha Kar: University of Cambridge, Strangeways Research Laboratory
Ji-Heui Seo: The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute
Jonathan Tyrer: University of Cambridge, Strangeways Research Laboratory
Tassja J. Spindler: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Janet Lee: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Yibu Chen: Bioinformatics Service, Norris Medical Library, University of Southern California
Alison Karst: Dana-Farber Cancer Institute
Ronny Drapkin: Dana-Farber Cancer Institute
Katja K. H. Aben: Radboud University Medical Centre
Hoda Anton-Culver: Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine
Natalia Antonenkova: Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N.
Helen Baker: University of Cambridge, Strangeways Research Laboratory
Elisa V. Bandera: Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey
Yukie Bean: Oregon Health and Science University
Matthias W. Beckmann: University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN
Andrew Berchuck: Duke University Medical Center
Maria Bisogna: Gynecology Service, Memorial Sloan Kettering Cancer Center
Line Bjorge: Haukeland University Hospital
Natalia Bogdanova: Gynaecology Research Unit, Hannover Medical School
Louise A. Brinton: National Cancer Institute
Angela Brooks-Wilson: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Fiona Bruinsma: Cancer Epidemiology Centre, Cancer Council Victoria
Ralf Butzow: University of Helsinki and Helsinki University Central Hospital
Ian G. Campbell: Cancer Genetics Laboratory, Peter MacCallum Cancer Centre
Karen Carty: Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre
Jenny Chang-Claude: German Cancer Research Center (DKFZ)
Georgia Chenevix-Trench: QIMR Berghofer Medical Research Institute
Anne Chen: Moffitt Cancer Center
Zhihua Chen: Moffitt Cancer Center
Linda S. Cook: University of New Mexico
Daniel W. Cramer: Harvard School of Public Health
Julie M. Cunningham: Mayo Clinic
Cezary Cybulski: Pomeranian Medical University
Agnieszka Dansonka-Mieszkowska: Pomeranian Medical University
Joe Dennis: Centre for Cancer Genetic Epidemiology, University of Cambridge
Ed Dicks: University of Cambridge, Strangeways Research Laboratory
Jennifer A. Doherty: The Geisel School of Medicine at Dartmouth
Thilo Dörk: Gynaecology Research Unit, Hannover Medical School
Andreas du Bois: Kliniken Essen-Mitte
Matthias Dürst: Jena University Hospital—Friedrich Schiller University
Diana Eccles: Faculty of Medicine, University of Southampton
Douglas T. Easton: Centre for Cancer Genetic Epidemiology, University of Cambridge
Robert P. Edwards: Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine
Ursula Eilber: German Cancer Research Center (DKFZ)
Arif B. Ekici: University Hospital Erlangen, Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg
Peter A. Fasching: University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN
Brooke L. Fridley: Biostatistics and Informatics Shared Resource, University of Kansas Medical Center
Yu-Tang Gao: Shanghai Cancer Institute
Aleksandra Gentry-Maharaj: Institute for Women’s Health, University College London
Graham G. Giles: Cancer Epidemiology Centre, Cancer Council Victoria
Rosalind Glasspool: Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre
Ellen L. Goode: Mayo Clinic
Marc T. Goodman: Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Jacek Grownwald: Pomeranian Medical University
Patricia Harrington: Centre for Cancer Genetic Epidemiology, University of Cambridge
Philipp Harter: Kliniken Essen-Mitte
Hanis Nazihah Hasmad: Cancer Research Initiatives Foundation, Sime Darby Medical Centre
Alexander Hein: University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN
Florian Heitz: Kliniken Essen-Mitte
Michelle A. T. Hildebrandt: The University of Texas MD Anderson Cancer Center
Peter Hillemanns: Hannover Medical School
Estrid Hogdall: Institute of Cancer Epidemiology, Danish Cancer Society
Claus Hogdall: Gyn Clinic, Rigshospitalet, University of Copenhagen
Satoyo Hosono: Aichi Cancer Center Research Institute
Edwin S. Iversen: Duke University
Anna Jakubowska: Pomeranian Medical University
Paul James: Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre
Allan Jensen: Rigshospitalet, University of Copenhagen
Bu-Tian Ji: National Cancer Institute
Beth Y. Karlan: Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Susanne Kruger Kjaer: Lifestyle and Genes, Danish Cancer Society Research Center
Linda E. Kelemen: College of Medicine, Medical University of South Carolina
Melissa Kellar: Oregon Health and Science University
Joseph L. Kelley: Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine
Lambertus A. Kiemeney: Radboud University Medical Mentre, Radboud Institute for Health Sciences
Camilla Krakstad: Haukeland University Hospital
Jolanta Kupryjanczyk: Pomeranian Medical University
Diether Lambrechts: Vesalius Research Center, VIB
Sandrina Lambrechts: University Hospitals Leuven
Nhu D. Le: Cancer Control Research, BC Cancer Agency
Alice W. Lee: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Shashi Lele: Roswell Park Cancer Institute
Arto Leminen: University of Helsinki and Helsinki University Central Hospital
Jenny Lester: Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Douglas A. Levine: Gynecology Service, Memorial Sloan Kettering Cancer Center
Dong Liang: College of Pharmacy and Health Sciences, Texas Southern University
Jolanta Lissowska: Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
Karen Lu: The University of Texas MD Anderson Cancer Center
Jan Lubinski: Pomeranian Medical University
Lene Lundvall: Molecular Unit, Herlev Hospital, University of Copenhagen
Leon F. A. G. Massuger: Radboud University Medical Centre
Keitaro Matsuo: Kyushu University Faculty of Medical Sciences
Valerie McGuire: Stanford University School of Medicine
John R. McLaughlin: Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Heli Nevanlinna: University of Helsinki and Helsinki University Central Hospital
Ian McNeish: Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, University of Glasgow
Usha Menon: Institute for Women’s Health, University College London
Francesmary Modugno: Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine
Kirsten B. Moysich: Roswell Park Cancer Institute
Steven A. Narod: Memorial Sloan Kettering Cancer Center
Lotte Nedergaard: Rigshospitalet, University of Copenhagen
Roberta B. Ness: The University of Texas School of Public Health
Mat Adenan Noor Azmi: University Malaya Medical Centre, University Malaya
Kunle Odunsi: Roswell Park Cancer Institute
Sara H. Olson: Memorial Sloan Kettering Cancer Center
Irene Orlow: Memorial Sloan Kettering Cancer Center
Sandra Orsulic: Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Rachel Palmieri Weber: Duke University Medical Center
Celeste L. Pearce: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Tanja Pejovic: Oregon Health and Science University
Liisa M. Pelttari: University of Helsinki and Helsinki University Central Hospital
Jennifer Permuth-Wey: Moffitt Cancer Center
Catherine M. Phelan: Moffitt Cancer Center
Malcolm C. Pike: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Elizabeth M. Poole: Brigham and Women’s Hospital and Harvard Medical School
Susan J. Ramus: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Harvey A. Risch: Yale School of Public Health
Barry Rosen: Princess Margaret Hospital, Faculty of Medicine, University of Toronto
Mary Anne Rossing: Program in Epidemiology, Fred Hutchinson Cancer Research Center
Joseph H. Rothstein: Stanford University School of Medicine
Anja Rudolph: German Cancer Research Center (DKFZ)
Ingo B. Runnebaum: Jena University Hospital—Friedrich Schiller University
Iwona K. Rzepecka: Pomeranian Medical University
Helga B. Salvesen: Haukeland University Hospital
Joellen M. Schildkraut: Cancer Control and Population Sciences, Duke Cancer Institute
Ira Schwaab: Institut für Humangenetik Wiesbaden
Thomas A. Sellers: Moffitt Cancer Center
Xiao-Ou Shu: Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
Yurii B. Shvetsov: Cancer Epidemiology Program, University of Hawaii Cancer Center
Nadeem Siddiqui: Glasgow Royal Infirmary
Weiva Sieh: Stanford University School of Medicine
Honglin Song: University of Cambridge, Strangeways Research Laboratory
Melissa C. Southey: University of Melbourne
Lara Sucheston: Roswell Park Cancer Institute
Ingvild L. Tangen: Haukeland University Hospital
Soo-Hwang Teo: Cancer Research Initiatives Foundation, Sime Darby Medical Centre
Kathryn L. Terry: University of New Mexico
Pamela J. Thompson: Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Agnieszka Timorek: Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital
Ya-Yu Tsai: Moffitt Cancer Center
Shelley S. Tworoger: Brigham and Women’s Hospital and Harvard Medical School
Anne M. van Altena: Radboud University Medical Centre
Els Van Nieuwenhuysen: University Hospitals Leuven
Ignace Vergote: University Hospitals Leuven
Robert A. Vierkant: Mayo Clinic
Shan Wang-Gohrke: University of Ulm
Christine Walsh: Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Nicolas Wentzensen: National Cancer Institute
Alice S. Whittemore: Stanford University School of Medicine
Kristine G. Wicklund: Program in Epidemiology, Fred Hutchinson Cancer Research Center
Lynne R. Wilkens: Cancer Epidemiology Program, University of Hawaii Cancer Center
Yin-Ling Woo: University Malaya Medical Centre, University Malaya
Xifeng Wu: The University of Texas MD Anderson Cancer Center
Anna H. Wu: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Hannah Yang: National Cancer Institute
Wei Zheng: Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
Argyrios Ziogas: Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine
Alvaro Monteiro: Cancer Epidemiology Program, H. Lee Moffitt Cancer Center & Research Institute
Paul D. Pharoah: University of Cambridge, Strangeways Research Laboratory
Simon A. Gayther: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Matthew L. Freedman: The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute

Nature Communications, 2015, vol. 6, issue 1, 1-14

Abstract: Abstract Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate cis-eQTL associations at 47 regions associated with HGSOC risk (P≤10−5). For three cis-eQTL associations (P

Date: 2015
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DOI: 10.1038/ncomms9234

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