Functional classification of memory CD8+ T cells by CX3CR1 expression

Jan P. Böttcher, Marc Beyer, Felix Meissner, Zeinab Abdullah, Jil Sander, Bastian Höchst, Sarah Eickhoff, Jan C. Rieckmann, Caroline Russo, Tanja Bauer, Tobias Flecken, Dominik Giesen, Daniel Engel, Steffen Jung, Dirk H. Busch, Ulrike Protzer, Robert Thimme, Matthias Mann, Christian Kurts, Joachim L. Schultze, Wolfgang Kastenmüller and Percy A. Knolle ()
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Jan P. Böttcher: Institute of Experimental Immunology, Universitätsklinikum Bonn
Marc Beyer: Genomics and Immunoregulation, LIMES-Institute, Universität Bonn
Felix Meissner: Max Planck Institute of Biochemistry
Zeinab Abdullah: Institute of Experimental Immunology, Universitätsklinikum Bonn
Jil Sander: Genomics and Immunoregulation, LIMES-Institute, Universität Bonn
Bastian Höchst: Institute of Molecular Immunology and Experimental Oncology, Technische Universität München
Sarah Eickhoff: Institute of Experimental Immunology, Universitätsklinikum Bonn
Jan C. Rieckmann: Max Planck Institute of Biochemistry
Caroline Russo: Institute of Virology, Technische Universität München
Tanja Bauer: Institute of Virology, Technische Universität München
Tobias Flecken: Clinic for Internal Medicine II, Universitätsklinikum Freiburg
Dominik Giesen: Clinic for Internal Medicine II, Universitätsklinikum Freiburg
Daniel Engel: Institute of Experimental Immunology, Universitätsklinikum Bonn
Steffen Jung: Weizmann Institute of Science
Dirk H. Busch: Institute of Microbiology, Immunology and Hygiene, Technische Universität München
Ulrike Protzer: Institute of Virology, Technische Universität München
Robert Thimme: Clinic for Internal Medicine II, Universitätsklinikum Freiburg
Matthias Mann: Max Planck Institute of Biochemistry
Christian Kurts: Institute of Experimental Immunology, Universitätsklinikum Bonn
Joachim L. Schultze: Genomics and Immunoregulation, LIMES-Institute, Universität Bonn
Wolfgang Kastenmüller: Institute of Experimental Immunology, Universitätsklinikum Bonn
Percy A. Knolle: Institute of Experimental Immunology, Universitätsklinikum Bonn

Nature Communications, 2015, vol. 6, issue 1, 1-17

Abstract: Abstract Localization of memory CD8+ T cells to lymphoid or peripheral tissues is believed to correlate with proliferative capacity or effector function. Here we demonstrate that the fractalkine-receptor/CX3CR1 distinguishes memory CD8+ T cells with cytotoxic effector function from those with proliferative capacity, independent of tissue-homing properties. CX3CR1-based transcriptome and proteome-profiling defines a core signature of memory CD8+ T cells with effector function. We find CD62LhiCX3CR1+ memory T cells that reside within lymph nodes. This population shows distinct migration patterns and positioning in proximity to pathogen entry sites. Virus-specific CX3CR1+ memory CD8+ T cells are scarce during chronic infection in humans and mice but increase when infection is controlled spontaneously or by therapeutic intervention. This CX3CR1-based functional classification will help to resolve the principles of protective CD8+ T-cell memory.

Date: 2015
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DOI: 10.1038/ncomms9306

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