Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis

Peter Zanvit, Joanne E. Konkel, Xue Jiao, Shimpei Kasagi, Dunfang Zhang, Ruiqing Wu, Cheryl Chia, Nadim J. Ajami, Daniel P. Smith, Joseph F. Petrosino, Brittany Abbatiello, Hiroko Nakatsukasa, Qianming Chen, Yasmine Belkaid, Zi-Jiang Chen and WanJun Chen ()
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Peter Zanvit: Mucosal Immunology Section, OPCB, NIDCR, NIH
Joanne E. Konkel: Mucosal Immunology Section, OPCB, NIDCR, NIH
Xue Jiao: Mucosal Immunology Section, OPCB, NIDCR, NIH
Shimpei Kasagi: Mucosal Immunology Section, OPCB, NIDCR, NIH
Dunfang Zhang: Mucosal Immunology Section, OPCB, NIDCR, NIH
Ruiqing Wu: Mucosal Immunology Section, OPCB, NIDCR, NIH
Cheryl Chia: Mucosal Immunology Section, OPCB, NIDCR, NIH
Nadim J. Ajami: The Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine
Daniel P. Smith: The Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine
Joseph F. Petrosino: The Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine
Brittany Abbatiello: Mucosal Immunology Section, OPCB, NIDCR, NIH
Hiroko Nakatsukasa: Mucosal Immunology Section, OPCB, NIDCR, NIH
Qianming Chen: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University
Yasmine Belkaid: Laboratory of Parasitic Diseases, NIAID, NIH
Zi-Jiang Chen: Center of Reproductive Medicine, Shandong Provincial Hospital, Shandong University
WanJun Chen: Mucosal Immunology Section, OPCB, NIDCR, NIH

Nature Communications, 2015, vol. 6, issue 1, 1-10

Abstract: Abstract Psoriasis is an inflammatory skin disease affecting ∼2% of the world’s population, but the aetiology remains incompletely understood. Recently, microbiota have been shown to differentially regulate the development of autoimmune diseases, but their influence on psoriasis is incompletely understood. We show here that adult mice treated with antibiotics that target Gram-negative and Gram-positive bacteria develop ameliorated psoriasiform dermatitis induced by imiquimod, with decreased pro-inflammatory IL-17- and IL-22-producing T cells. Surprisingly, mice treated neonatally with these antibiotics develop exacerbated psoriasis induced by imiquimod or recombinant IL-23 injection when challenged as adults, with increased IL-22-producing γδ+ T cells. 16S rRNA gene compositional analysis reveals that neonatal antibiotic-treatment dysregulates gut and skin microbiota in adults, which is associated with increased susceptibility to experimental psoriasis. This link between neonatal antibiotic-mediated imbalance in microbiota and development of experimental psoriasis provides precedence for further investigation of its specific aetiology as it relates to human psoriasis.

Date: 2015
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DOI: 10.1038/ncomms9424

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