Limited dissemination of the wastewater treatment plant core resistome

Christian Munck, Mads Albertsen, Amar Telke, Mostafa Ellabaan, Per Halkjær Nielsen and Morten O. A. Sommer ()
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Christian Munck: Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2970 Hørsholm, Denmark
Mads Albertsen: Center for Microbial Communities, Aalborg University
Amar Telke: Technical University of Denmark
Mostafa Ellabaan: Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2970 Hørsholm, Denmark
Per Halkjær Nielsen: Center for Microbial Communities, Aalborg University
Morten O. A. Sommer: Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2970 Hørsholm, Denmark

Nature Communications, 2015, vol. 6, issue 1, 1-10

Abstract: Abstract Horizontal gene transfer is a major contributor to the evolution of bacterial genomes and can facilitate the dissemination of antibiotic resistance genes between environmental reservoirs and potential pathogens. Wastewater treatment plants (WWTPs) are believed to play a central role in the dissemination of antibiotic resistance genes. However, the contribution of the dominant members of the WWTP resistome to resistance in human pathogens remains poorly understood. Here we use a combination of metagenomic functional selections and comprehensive metagenomic sequencing to uncover the dominant genes of the WWTP resistome. We find that this core resistome is unique to the WWTP environment, with

Date: 2015
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DOI: 10.1038/ncomms9452

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