Sleep disruption impairs haematopoietic stem cell transplantation in mice

Asya Rolls, Wendy W. Pang, Ingrid Ibarra, Damien Colas, Patricia Bonnavion, Ben Korin, H. Craig Heller, Irving L. Weissman () and Luis de Lecea ()
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Asya Rolls: Stanford University
Wendy W. Pang: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
Ingrid Ibarra: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
Damien Colas: Stanford University
Patricia Bonnavion: Stanford University
Ben Korin: Rappaport Medical School, Technion, Israel Institute of Technology
H. Craig Heller: Stanford University
Irving L. Weissman: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
Luis de Lecea: Stanford University

Nature Communications, 2015, vol. 6, issue 1, 1-9

Abstract: Abstract Many of the factors affecting the success of haematopoietic cell transplantation are still unknown. Here we show in mice that donor sleep deprivation reduces the ability of its haematopoietic stem cells (HSCs) to engraft and reconstitute the blood and bone marrow of an irradiated recipient by more than 50%. We demonstrate that sleep deprivation downregulates the expression of microRNA (miR)-19b, a negative regulator of the suppressor of cytokine signalling (SOCS) genes, which inhibit HSC migration and homing. Accordingly, HSCs from sleep-deprived mice have higher levels of SOCS genes expression, lower migration capacity in vitro and reduced homing to the bone marrow in vivo. Recovery of sleep after sleep deprivation restored the reconstitution potential of the HSCs. Taken together, this study provides insights into cellular and molecular mechanisms underlying the effects of sleep deprivation on HSCs, emphasizing the potentially critical role of donor sleep in the success of bone marrow transplantation.

Date: 2015
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DOI: 10.1038/ncomms9516

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