Theta oscillations regulate the speed of locomotion via a hippocampus to lateral septum pathway

Franziska Bender, Maria Gorbati, Marta Carus Cadavieco, Natalia Denisova, Xiaojie Gao, Constance Holman, Tatiana Korotkova () and Alexey Ponomarenko ()
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Franziska Bender: Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
Maria Gorbati: Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
Marta Carus Cadavieco: Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
Natalia Denisova: Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
Xiaojie Gao: Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
Constance Holman: Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
Tatiana Korotkova: Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
Alexey Ponomarenko: Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)

Nature Communications, 2015, vol. 6, issue 1, 1-11

Abstract: Abstract Hippocampal theta oscillations support encoding of an animal’s position during spatial navigation, yet longstanding questions about their impact on locomotion remain unanswered. Combining optogenetic control of hippocampal theta oscillations with electrophysiological recordings in mice, we show that hippocampal theta oscillations regulate locomotion. In particular, we demonstrate that their regularity underlies more stable and slower running speeds during exploration. More regular theta oscillations are accompanied by more regular theta-rhythmic spiking output of pyramidal cells. Theta oscillations are coordinated between the hippocampus and its main subcortical output, the lateral septum (LS). Chemo- or optogenetic inhibition of this pathway reveals its necessity for the hippocampal regulation of running speed. Moreover, theta-rhythmic stimulation of LS projections to the lateral hypothalamus replicates the reduction of running speed induced by more regular hippocampal theta oscillations. These results suggest that changes in hippocampal theta synchronization are translated into rapid adjustment of running speed via the LS.

Date: 2015
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DOI: 10.1038/ncomms9521

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