Genome-wide association study identifies multiple susceptibility loci for glioma

Ben Kinnersley, Marianne Labussière, Amy Holroyd, Anna-Luisa Di Stefano, Peter Broderick, Jayaram Vijayakrishnan, Karima Mokhtari, Jean-Yves Delattre, Konstantinos Gousias, Johannes Schramm, Minouk J. Schoemaker, Sarah J. Fleming, Stefan Herms, Stefanie Heilmann, Stefan Schreiber, Heinz-Erich Wichmann, Markus M. Nöthen, Anthony Swerdlow, Mark Lathrop, Matthias Simon, Melissa Bondy, Marc Sanson and Richard S. Houlston ()
Additional contact information
Ben Kinnersley: The Institute of Cancer Research
Marianne Labussière: Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM
Amy Holroyd: The Institute of Cancer Research
Anna-Luisa Di Stefano: Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM
Peter Broderick: The Institute of Cancer Research
Jayaram Vijayakrishnan: The Institute of Cancer Research
Karima Mokhtari: Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM
Jean-Yves Delattre: Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM
Konstantinos Gousias: University of Bonn Medical Center
Johannes Schramm: University of Bonn Medical Center
Minouk J. Schoemaker: The Institute of Cancer Research
Sarah J. Fleming: Centre for Epidemiology and Biostatistics, Faculty of Medicine and Health, University of Leeds
Stefan Herms: Institute of Human Genetics, University of Bonn
Stefanie Heilmann: Institute of Human Genetics, University of Bonn
Stefan Schreiber: University Clinic Schleswig-Holstein
Heinz-Erich Wichmann: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health
Markus M. Nöthen: Institute of Human Genetics, University of Bonn
Anthony Swerdlow: The Institute of Cancer Research
Mark Lathrop: AP-HP, GH Pitié-Salpêtrière, Laboratoire de neuropathologie R Escourolle
Matthias Simon: University of Bonn Medical Center
Melissa Bondy: Dan L. Duncan Cancer Center, Baylor College of Medicine
Marc Sanson: Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM
Richard S. Houlston: The Institute of Cancer Research

Nature Communications, 2015, vol. 6, issue 1, 1-9

Abstract: Abstract Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project data as reference. After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10−9) and non-GBM at 10q25.2 (rs11196067, near VTI1A, P=4.32 × 10−8), 11q23.2 (rs648044, near ZBTB16, P=6.26 × 10−11), 12q21.2 (rs12230172, P=7.53 × 10−11) and 15q24.2 (rs1801591, near ETFA, P=5.71 × 10−9). Our findings provide further insights into the genetic basis of the different glioma subtypes.

Date: 2015
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DOI: 10.1038/ncomms9559

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