The Lin28/let-7 axis is critical for myelination in the peripheral nervous system

Deniz Gökbuget, Jorge A. Pereira, Sven Bachofner, Antonin Marchais, Constance Ciaudo, Markus Stoffel, Johannes H. Schulte and Ueli Suter ()
Additional contact information
Deniz Gökbuget: Institute of Molecular Health Sciences, ETH Zurich
Jorge A. Pereira: Institute of Molecular Health Sciences, ETH Zurich
Sven Bachofner: Institute of Molecular Health Sciences, ETH Zurich
Antonin Marchais: Institute of Agricultural Sciences, ETH Zurich
Constance Ciaudo: Institute of Molecular Health Sciences, ETH Zurich
Markus Stoffel: Institute of Molecular Health Sciences, ETH Zurich
Johannes H. Schulte: Children's Hospital Essen
Ueli Suter: Institute of Molecular Health Sciences, ETH Zurich

Nature Communications, 2015, vol. 6, issue 1, 1-9

Abstract: Abstract MicroRNAs (miRNAs) are crucial regulators of myelination in the peripheral nervous system (PNS). However, the miRNAs species involved and the underlying mechanisms are largely unknown. We found that let-7 miRNAs are highly abundant during PNS myelination and that their levels are inversely correlated to the expression of lin28 homolog B (Lin28B), an antagonist of let-7 accumulation. Sustained expression of Lin28B and consequently reduced levels of let-7 miRNAs results in a failure of Schwann cell myelination in transgenic mouse models and in cell culture. Subsequent analyses revealed that let-7 miRNAs promote expression of the myelination-driving master transcription factor Krox20 (also known as Egr2) through suppression of myelination inhibitory Notch signalling. We conclude that the Lin28B/let-7 axis acts as a critical driver of PNS myelination, in particular by regulating myelination onset, identifying this pathway also as a potential therapeutic target in demyelinating diseases.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms9584 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9584

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms9584

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().