Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

María Soler Artigas, Louise V. Wain, Suzanne Miller, Abdul Kader Kheirallah, Jennifer E. Huffman, Ioanna Ntalla, Nick Shrine, Ma’en Obeidat, Holly Trochet, Wendy L. McArdle, Alexessander Couto Alves, Jennie Hui, Jing Hua Zhao, Peter K. Joshi, Alexander Teumer, Eva Albrecht, Medea Imboden, Rajesh Rawal, Lorna M. Lopez, Jonathan Marten, Stefan Enroth, Ida Surakka, Ozren Polasek, Leo-Pekka Lyytikäinen, Raquel Granell, Pirro G. Hysi, Claudia Flexeder, Anubha Mahajan, John Beilby, Yohan Bossé, Corry-Anke Brandsma, Harry Campbell, Christian Gieger, Sven Gläser, Juan R. González, Harald Grallert, Chris J. Hammond, Sarah E. Harris, Anna-Liisa Hartikainen, Markku Heliövaara, John Henderson, Lynne Hocking, Momoko Horikoshi, Nina Hutri-Kähönen, Erik Ingelsson, Åsa Johansson, John P. Kemp, Ivana Kolcic, Ashish Kumar, Lars Lind, Erik Melén, Arthur W. Musk, Pau Navarro, David C. Nickle, Sandosh Padmanabhan, Olli T. Raitakari, Janina S. Ried, Samuli Ripatti, Holger Schulz, Robert A. Scott, Don D. Sin, John M. Starr, Ana Viñuela, Henry Völzke, Sarah H. Wild, Alan F. Wright, Tatijana Zemunik, Deborah L. Jarvis, Tim D. Spector, David M. Evans, Terho Lehtimäki, Veronique Vitart, Mika Kähönen, Ulf Gyllensten, Igor Rudan, Ian J. Deary, Stefan Karrasch, Nicole M. Probst-Hensch, Joachim Heinrich, Beate Stubbe, James F. Wilson, Nicholas J. Wareham, Alan L. James, Andrew P. Morris, Marjo-Riitta Jarvelin, Caroline Hayward, Ian Sayers, David P. Strachan, Ian P. Hall () and Martin D. Tobin ()
Additional contact information
María Soler Artigas: Genetic Epidemiology Group, University of Leicester
Louise V. Wain: Genetic Epidemiology Group, University of Leicester
Suzanne Miller: Queen’s Medical Centre, University of Nottingham
Abdul Kader Kheirallah: Queen’s Medical Centre, University of Nottingham
Jennifer E. Huffman: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
Ioanna Ntalla: Genetic Epidemiology Group, University of Leicester
Nick Shrine: Genetic Epidemiology Group, University of Leicester
Ma’en Obeidat: University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital
Holly Trochet: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
Wendy L. McArdle: School of Social and Community Medicine, University of Bristol
Alexessander Couto Alves: MRC -PHE Centre for Environment & Health, School of Public Health, Imperial College London
Jennie Hui: Busselton Population Medical Research Institute
Jing Hua Zhao: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
Peter K. Joshi: Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Alexander Teumer: University Medicine Greifswald, Community Medicine, SHIP—Clinical Epidemiological Research
Eva Albrecht: Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health
Medea Imboden: Swiss Tropical and Public Health Institute
Rajesh Rawal: Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health
Lorna M. Lopez: Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
Jonathan Marten: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
Stefan Enroth: Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University
Ida Surakka: Institute for Molecular Medicine Finland (FIMM), University of Helsinki
Ozren Polasek: Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Leo-Pekka Lyytikäinen: Fimlab Laboratories
Raquel Granell: School of Social and Community Medicine, University of Bristol
Pirro G. Hysi: King's College London
Claudia Flexeder: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health
Anubha Mahajan: Wellcome Trust Centre for Human Genetics, University of Oxford
John Beilby: Busselton Population Medical Research Institute
Yohan Bossé: Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University
Corry-Anke Brandsma: University of Groningen, University Medical Center Groningen
Harry Campbell: Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Christian Gieger: Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health
Sven Gläser: Pneumology, Cardiology, Intensive Care, Weaning, Field of Research: Pneumological Epidemiology, University Medicine Greifswald
Juan R. González: Centre for Research in Environmental Epidemiology (CREAL)
Harald Grallert: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Chris J. Hammond: King's College London
Sarah E. Harris: Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
Anna-Liisa Hartikainen: Department of Obstetrics and Gynecology of Oulu University Hospital ,MRC of Oulu University
Markku Heliövaara: The National Institute for Health and Welfare (THL)
John Henderson: School of Social and Community Medicine, University of Bristol
Lynne Hocking: Generation Scotland, A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee
Momoko Horikoshi: Wellcome Trust Centre for Human Genetics, University of Oxford
Nina Hutri-Kähönen: Tampere University Hospital
Erik Ingelsson: Wellcome Trust Centre for Human Genetics, University of Oxford
Åsa Johansson: Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University
John P. Kemp: School of Social and Community Medicine, University of Bristol
Ivana Kolcic: Faculty of Medicine, University of Split
Ashish Kumar: Swiss Tropical and Public Health Institute
Lars Lind: Uppsala University
Erik Melén: Institute of Environmental Medicine, Karolinska Institutet and Sachs’ Children’s Hospital
Arthur W. Musk: Busselton Population Medical Research Institute
Pau Navarro: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
David C. Nickle: Genetics and Pharmacogenomics, Merck Research Labs
Sandosh Padmanabhan: Generation Scotland, A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee
Olli T. Raitakari: Turku University Hospital
Janina S. Ried: Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health
Samuli Ripatti: Institute for Molecular Medicine Finland (FIMM), University of Helsinki
Holger Schulz: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health
Robert A. Scott: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
Don D. Sin: University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital
John M. Starr: Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
Ana Viñuela: King's College London
Henry Völzke: University Medicine Greifswald, Community Medicine, SHIP—Clinical Epidemiological Research
Sarah H. Wild: Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Alan F. Wright: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
Tatijana Zemunik: Faculty of Medicine, University of Split
Deborah L. Jarvis: Respiratory Epidemiology and Public Health, Imperial College London
Tim D. Spector: King's College London
David M. Evans: School of Social and Community Medicine, University of Bristol
Terho Lehtimäki: Fimlab Laboratories
Veronique Vitart: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
Mika Kähönen: University of Tampere and Tampere University Hospital
Ulf Gyllensten: Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University
Igor Rudan: Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Ian J. Deary: Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
Stefan Karrasch: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health
Nicole M. Probst-Hensch: Swiss Tropical and Public Health Institute
Joachim Heinrich: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health
Beate Stubbe: Pneumology, Cardiology, Intensive Care, Weaning, Field of Research: Pneumological Epidemiology, University Medicine Greifswald
James F. Wilson: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
Nicholas J. Wareham: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
Alan L. James: Busselton Population Medical Research Institute
Andrew P. Morris: Wellcome Trust Centre for Human Genetics, University of Oxford
Marjo-Riitta Jarvelin: MRC -PHE Centre for Environment & Health, School of Public Health, Imperial College London
Caroline Hayward: Generation Scotland, A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee
Ian Sayers: Queen’s Medical Centre, University of Nottingham
David P. Strachan: Population Health Research Institute, St George’s, University of London
Ian P. Hall: Queen’s Medical Centre, University of Nottingham
Martin D. Tobin: Genetic Epidemiology Group, University of Leicester

Nature Communications, 2015, vol. 6, issue 1, 1-12

Abstract: Abstract Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P

Date: 2015
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DOI: 10.1038/ncomms9658

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