Cytokinin response factors regulate PIN-FORMED auxin transporters

Mária Šimášková, José Antonio O’Brien, Mamoona Khan, Giel Van Noorden, Krisztina Ötvös, Anne Vieten, Inge De Clercq, Johanna Maria Adriana Van Haperen, Candela Cuesta, Klára Hoyerová, Steffen Vanneste, Peter Marhavý, Krzysztof Wabnik, Frank Van Breusegem, Moritz Nowack, Angus Murphy, Jiří Friml, Dolf Weijers, Tom Beeckman and Eva Benková ()
Additional contact information
Mária Šimášková: VIB
José Antonio O’Brien: VIB
Mamoona Khan: Institute of Science and Technology Austria (IST Austria)
Giel Van Noorden: VIB
Krisztina Ötvös: Institute of Science and Technology Austria (IST Austria)
Anne Vieten: Centre for Molecular Biology of Plants, University Tübingen
Inge De Clercq: VIB
Johanna Maria Adriana Van Haperen: Laboratory of Biochemistry, Wageningen University
Candela Cuesta: Institute of Science and Technology Austria (IST Austria)
Klára Hoyerová: Institute of Experimental Botany, ASCR
Steffen Vanneste: VIB
Peter Marhavý: Institute of Science and Technology Austria (IST Austria)
Krzysztof Wabnik: Institute of Science and Technology Austria (IST Austria)
Frank Van Breusegem: VIB
Moritz Nowack: VIB
Angus Murphy: University of Maryland
Jiří Friml: Institute of Science and Technology Austria (IST Austria)
Dolf Weijers: Laboratory of Biochemistry, Wageningen University
Tom Beeckman: VIB
Eva Benková: Institute of Science and Technology Austria (IST Austria)

Nature Communications, 2015, vol. 6, issue 1, 1-11

Abstract: Abstract Auxin and cytokinin are key endogenous regulators of plant development. Although cytokinin-mediated modulation of auxin distribution is a developmentally crucial hormonal interaction, its molecular basis is largely unknown. Here we show a direct regulatory link between cytokinin signalling and the auxin transport machinery uncovering a mechanistic framework for cytokinin-auxin cross-talk. We show that the CYTOKININ RESPONSE FACTORS (CRFs), transcription factors downstream of cytokinin perception, transcriptionally control genes encoding PIN-FORMED (PIN) auxin transporters at a specific PIN CYTOKININ RESPONSE ELEMENT (PCRE) domain. Removal of this cis-regulatory element effectively uncouples PIN transcription from the CRF-mediated cytokinin regulation and attenuates plant cytokinin sensitivity. We propose that CRFs represent a missing cross-talk component that fine-tunes auxin transport capacity downstream of cytokinin signalling to control plant development.

Date: 2015
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DOI: 10.1038/ncomms9717

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