Identification and characterization of latency-associated peptide-expressing γδ T cells

Rafael M. Rezende, Andre P. da Cunha, Chantal Kuhn, Stephen Rubino, Hanane M’Hamdi, Galina Gabriely, Tyler Vandeventer, Shirong Liu, Ron Cialic, Natalia Pinheiro-Rosa, Rafael P. Oliveira, Jellert T. Gaublomme, Nikolaus Obholzer, James Kozubek, Nathalie Pochet, Ana M. C. Faria and Howard L. Weiner ()
Additional contact information
Rafael M. Rezende: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Andre P. da Cunha: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Chantal Kuhn: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Stephen Rubino: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Hanane M’Hamdi: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Galina Gabriely: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Tyler Vandeventer: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Shirong Liu: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Ron Cialic: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Natalia Pinheiro-Rosa: Institute of Biological Sciences, Federal University of Minas Gerais
Rafael P. Oliveira: Institute of Biological Sciences, Federal University of Minas Gerais
Jellert T. Gaublomme: Harvard University
Nikolaus Obholzer: Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Women’s Hospital
James Kozubek: Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Women’s Hospital
Nathalie Pochet: Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Women’s Hospital
Ana M. C. Faria: Institute of Biological Sciences, Federal University of Minas Gerais
Howard L. Weiner: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School

Nature Communications, 2015, vol. 6, issue 1, 1-12

Abstract: Abstract γδ T cells are a subset of lymphocytes specialized in protecting the host against pathogens and tumours. Here we describe a subset of regulatory γδ T cells that express the latency-associated peptide (LAP), a membrane-bound TGF-β1. Thymic CD27+IFN-γ+CCR9+α4β7+TCRγδ+ cells migrate to the periphery, particularly to Peyer’s patches and small intestine lamina propria, where they upregulate LAP, downregulate IFN-γ via ATF-3 expression and acquire a regulatory phenotype. TCRγδ+LAP+ cells express antigen presentation molecules and function as antigen presenting cells that induce CD4+Foxp3+ regulatory T cells, although TCRγδ+LAP+ cells do not themselves express Foxp3. Identification of TCRγδ+LAP+ regulatory cells provides an avenue for understanding immune regulation and biologic processes linked to intestinal function and disease.

Date: 2015
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DOI: 10.1038/ncomms9726

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