Gut mucosal microbiome across stages of colorectal carcinogenesis

Geicho Nakatsu, Xiangchun Li, Haokui Zhou, Jianqiu Sheng, Sunny Hei Wong, William Ka Kai Wu, Siew Chien Ng, Ho Tsoi, Yujuan Dong, Ning Zhang, Yuqi He, Qian Kang, Lei Cao, Kunning Wang, Jingwan Zhang, Qiaoyi Liang, Jun Yu () and Joseph J. Y. Sung ()
Additional contact information
Geicho Nakatsu: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Xiangchun Li: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Haokui Zhou: The Chinese University of Hong Kong
Jianqiu Sheng: Beijing Military General Hospital
Sunny Hei Wong: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
William Ka Kai Wu: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Siew Chien Ng: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Ho Tsoi: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Yujuan Dong: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Ning Zhang: The First Affiliated Hospital of Sun Yat-sen University
Yuqi He: Beijing Military General Hospital
Qian Kang: Beijing Military General Hospital
Lei Cao: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Kunning Wang: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Jingwan Zhang: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Qiaoyi Liang: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Jun Yu: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Joseph J. Y. Sung: Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong

Nature Communications, 2015, vol. 6, issue 1, 1-9

Abstract: Abstract Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). Here we catalogue the microbial communities in human gut mucosae at different stages of colorectal tumorigenesis. We analyse the gut mucosal microbiome of 47 paired samples of adenoma and adenoma-adjacent mucosae, 52 paired samples of carcinoma and carcinoma-adjacent mucosae and 61 healthy controls. Probabilistic partitioning of relative abundance profiles reveals that a metacommunity predominated by members of the oral microbiome is primarily associated with CRC. Analysis of paired samples shows differences in community configurations between lesions and the adjacent mucosae. Correlations of bacterial taxa indicate early signs of dysbiosis in adenoma, and co-exclusive relationships are subsequently more common in cancer. We validate these alterations in CRC-associated microbiome by comparison with two previously published data sets. Our results suggest that a taxonomically defined microbial consortium is implicated in the development of CRC.

Date: 2015
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DOI: 10.1038/ncomms9727

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